type 2 diabetes mellitus. Non-insulin-dependent diabetes mellitus
Conditions
Interventions
Intervention 1: L-carnitine, an oral supplement of 500 mg twice daily for 12 weeks in the intervention group. Intervention 2: placebo, 500 mg tablet twice a day for 12 weeks in the placebo group.
Treatment - Drugs
Placebo
L-carnitine, an oral supplement of 500 mg twice daily for 12 weeks in the intervention group
placebo, 500 mg tablet twice a day for 12 weeks in the placebo group
Sponsors
shahid sadughi yazd University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: inclusion criteria: Body mass index between 25 and 35; People aged 30 to 60 years old; Diabetes mellitus patients and HbA1c hemoglobin less than 9 percent and Exclusion criteria: Kidney disease; Hypothyroid patients who were not treated; People with blood pressure upper than 150/90 mm; Use of L-carnitine and B group vitamins during last 3 months; Antioxidant supplementation use (vitamins A, A, D and E) within 1 month Past; smoking ; liver and gastrointestinal diseases; having a systematic infection or surgery history 3 or 6 months ago; history of heart attacks, unstable angina or congestion.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum homocysteine. Timepoint: Before the intervention and three months after the intervention begin. Method of measurement: ELISA.;Total antioxidant capacity(TAC). Timepoint: Before the intervention and three months after the intervention begin. Method of measurement: ELISA.;Serum Total cholesterol. Timepoint: Before the intervention and three months after the intervention begin. Method of measurement: using Appropriate kits, by Alpha-Classic autoanalyzer.;Serum triglyceride level (TG). Timepoint: Before the intervention and three months after the intervention begin. Method of measurement: using Appropriate kits, by Alpha-Classic autoanalyzer.;Serum high density lipoprotein cholesterol (HDL-C). Timepoint: Before the intervention and three months after the intervention begin. Method of measurement: Using Appropriate kits, by Alpha-Classic autoanalyzer.;Serum fasting blood sugar(FBS). Timepoint: Before the intervention and three months after the intervention begin. Method of measurement: using Appropriate kits, by Alpha-Classic autoanalyzer.;Serum low Density Lipoprotein cholesterol (LDL-C). Timepoint: Before the intervention and three months after the intervention begin. Method of measurement: Using Appropriate kits, by Alpha-Classic autoanalyzer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Visceral fat percent. Timepoint: Before the intervention and three months after the intervention begin. Method of measurement: by body Calibrated scale.;Body fat percent. Timepoint: Before the intervention and three months after the intervention begin. Method of measurement: by body Calibrated scale.;BMI. Timepoint: Before the intervention and three months after the intervention begin. Method of measurement: by body Calibrated scale.;Weight. Timepoint: Before the intervention and three months after the intervention begin. Method of measurement: by body Calibrated scale.;Muscle mass percent. Timepoint: Before the intervention and three months after the intervention begin. Method of measurement: by body Calibrated scale.;Evalution of patients diet. Timepoint: Before the intervention and three months after the intervention begin. Method of measurement: Three-day food record. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNasir talenezhad
Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Outcome results
None listed