Comparison of the therapeutic effect of allopurinol versus placebo on clinical signs and symptoms in patients with manic bipolar disorder

Comparison of the therapeutic effect of allopurinol versus placebo on clinical signs and symptoms in patients with manic bipolar disorder: a double blind randomized clinical trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201710089014N193

Enrollment

Registered

2017-10-17

Start date

2007-10-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Manic bipolar disorder. Manic episode

Interventions

Intervention 1: Intervention group: Routine treatment plus allopurinol 300 mg twice a day orally for 4 weeks. Intervention 2: Control group: Routine treatment plus placebo capsule (including cellulose

Treatment - Drugs

Placebo

Intervention group: Routine treatment plus allopurinol 300 mg twice a day orally for 4 weeks.

Control group: Routine treatment plus placebo capsule (including cellulose) twice a day orally for 4 weeks.

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age of 18 to 45 years; manic bipolar disorder; Score of YMRS equal to or greater than28. Exclusion criteria: Pregnancy; breastfeeding; sensitivity to allopurinol; mental disability; diabetes; hypertension; hypothyroiditis; hyperthyroiditis; convulsion; liver failure; renal failure.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Severity of clinical signs and symptoms. Timepoint: Before intervention and one, two, three, and four weeks after intervention. Method of measurement: Using YMRS questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMozhdeh Rigi

Baharan Hospital

rigi.mozhdeh@gmail.com+98 37 7933 5154

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026