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Comparison of the Effect of General Anesthesia with Opioids vs Opioid Free Anesthesia on Postoperative Pain in Patients Undergoing Laparoscopic Cholecystectomy

Comparison of the Effect of General Anesthesia with Opioids vs Opioid Free Anesthesia on Postoperative Pain in Patients Undergoing Laparoscopic Cholecystectomy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20171004036548N1
Enrollment
160
Registered
2018-01-22
Start date
2016-09-22
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cholelithiasis. Calculus of gallbladder with other cholecystitis

Interventions

Intervention 1: The second group: Conventional Anesthesia Metod (with Opioid). The anesthesia will be administered by following drugs, including: Midazolam 0.03 mg/kg IV, Fentanyl 3 µ/kg, Propofol 2 m
Treatment - Drugs
The second group: Conventional Anesthesia Metod (with Opioid). The anesthesia will be administered by following drugs, including: Midazolam 0.03 mg/kg IV, Fentanyl 3 µ/kg, Propofol 2 mg/kg IV, Atracur
First group: Opioid-free anesthesia.The anesthesia will be administered by following drugs, including: Midazolam 0.03 mg/kg IV, Propofol 2 mg/kg IV, Atracurium 0.5 mg/kg IV, Lidocaine 1.5 mg/kg IV, fo

Sponsors

Kashan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age 18 - 65 years old Candidate for non-emergency Laparoscopic Cholecystectomy ASA Class 1, 2

Exclusion criteria

Exclusion criteria: Use of Opioid drugs within 24 hours before surgery Allergy to any medication used in the study Motion sickness Addiction Cardiac disease, Hypertention History of Sleep Apnea Gastrointestinal bleeding Parkinson's disease Liver and Kidney Diseases Emergency surgery Pregnancy BMI> 35

Design outcomes

Primary

MeasureTime frame
Nausa. Timepoint: In recovery and 3,6,12,24 hour after surgery. Method of measurement: Visual Analogue Scale.;Intensity of pain. Timepoint: In recovery and 3,6,12,24 hour after surgery. Method of measurement: Visual Analogue Scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAhmad Haddad

Kashan University of Medical Sciences

Dr.ahmadhaddad@yahoo.com+98 31 5542 0269

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026