The effectiveness of a topical form of Cassia fistula L. on Constipation

The effectiveness of a topical preparation of Cassia fistula L. on navel for the treatment of functional constipation

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170929036482N2

Enrollment

150

Registered

2018-10-24

Start date

2016-04-02

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Functional Constipation. Constipation

Interventions

Intervention 1: Patients were divided into two groups A and B. During the first two weeks, group A received Cassia fistula or placebo. Subsequently in one weeks, they did not receive any medication (w

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Age between 18 to 50 years Confirmation of functional constipation diagnosis based on Rome III criteria

Exclusion criteria

Exclusion criteria: Pregnancy, , , , , , , , Lactating women History of abdominal surgery Gastrointestinal bleeding Psychosis Recent surgery Serious Heart or Liver diseases or Endocrine disorders (Diabetes, Thyroid dysfunction) Cancer Anemia

Design outcomes

Primary

Measure	Time frame
Frequency of defecation per week. Timepoint: Before the study, end of week 2, end of week 4. Method of measurement: A questionnaire based on Rome III criteria.;Frequency of hard stool. Timepoint: Before the study, end of week 2, end of week 4. Method of measurement: A questionnaire based on Rome III criteria.;Frequency of straining during defecation. Timepoint: Before the study, end of week 2, end of week 4. Method of measurement: A questionnaire based on Rome III criteria.;Frequency of sensation of incomplate evacuation. Timepoint: Before the study, end of week 2, end of week 4. Method of measurement: A questionnaire based on Rome III criteria.;Frequency of sensation of anorectal blockage. Timepoint: Before the study, end of week 2, end of week 4. Method of measurement: A questionnaire based on Rome III criteria.;Frequency of manual maneuvers to facilitate defecation. Timepoint: Before the study, end of week 2, end of week 4. Method of measurement: A questionnaire based on Rome III criteria.	—

Measure

Time frame

Frequency of defecation per week. Timepoint: Before the study, end of week 2, end of week 4. Method of measurement: A questionnaire based on Rome III criteria.;Frequency of hard stool. Timepoint: Before the study, end of week 2, end of week 4. Method of measurement: A questionnaire based on Rome III criteria.;Frequency of straining during defecation. Timepoint: Before the study, end of week 2, end of week 4. Method of measurement: A questionnaire based on Rome III criteria.;Frequency of sensation of incomplate evacuation. Timepoint: Before the study, end of week 2, end of week 4. Method of measurement: A questionnaire based on Rome III criteria.;Frequency of sensation of anorectal blockage. Timepoint: Before the study, end of week 2, end of week 4. Method of measurement: A questionnaire based on Rome III criteria.;Frequency of manual maneuvers to facilitate defecation. Timepoint: Before the study, end of week 2, end of week 4. Method of measurement: A questionnaire based on Rome III criteria.

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Secondary

Measure	Time frame
Skin complication at the site of topical use. Timepoint: Before study, end of week 2, end of week 4. Method of measurement: A questionnaire.;Any possible complications. Timepoint: Before study, end of week 2, end of week 4. Method of measurement: A questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohsen Keshavarz

Tehran University

herbal_med777@yahoo.com+98 21 8899 3656

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026