Comparison of the effect of intravenous ibuprofen, intravenous acetaminophen, and intravenous morphine sulfate on treatment of abdominal pain in patients with appendicitis

Comparison of the effect of intravenous ibuprofen, intravenous acetaminophen, and intravenous morphine sulfate on treatment of abdominal pain in patients with appendicitis: a triple blind randomized clinical trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201709279014N190

Enrollment

105

Registered

2017-09-28

Start date

2017-10-07

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Appendicitis. Acute appendicitis

Interventions

Intervention 1: Intervention group 1: Intravenous infusion of ibuprofen 10 mg/kg plus 100 ml normal saline within 30 minutes. Intervention 2: Intervention group 2: Intravenous infusion of morphine sul

Treatment - Drugs

Intervention group 1: Intravenous infusion of ibuprofen 10 mg/kg plus 100 ml normal saline within 30 minutes.

Intervention group 2: Intravenous infusion of morphine sulfate 0.1 mg/kg plus 100 ml normal saline within 30 minutes.

Intervention group 3: Intravenous infusion of acetaminophen 10 mg/kg plus 100 ml normal saline within 30 minutes.

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age of 18 to 60 years; appendicitis; beginning of abdominal pain within past 24 hours. Exclusion criteria: Pregnancy; using analgesic within past 6 hours; using antibiotic within past 24 hours; chronic abdominal disease; addiction to narcotic; a history of gastrointestinal bleeding; coagulopathy; using medications such as warfarin, lithium, furosemide, or ACEI.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Assessing pain severity. Timepoint: Before intervention and 15, 30 and 60 minutes after intervention. Method of measurement: Using Visual Analog Scale (VAS).;Assessing nausea and vomiting. Timepoint: Before intervention and 15, 30 and 60 minutes after intervention. Method of measurement: Through history taking.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Hila Farokhpey Samami

Besat Hospital

hila_kool@hotmail.com+98 81 3364 0030

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026