depression. Major depressive disorder, single episode, unspecified
Conditions
Interventions
Intervention 1: Intervention group: Every two weeks receives 50000 IU vitamin D as vitamin D supplementation for 8 weeks, which is provided on a monthly basis. Intervention 2: Control group:Every two
Sponsors
National Nutrition and Food Technology Researc Institute
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: having mild to moderate depression age: 18 to 60 y
Exclusion criteria
Exclusion criteria: having a history of heart infarction having a history of angina having a history of stroke having a history of kidney stones having a history of high blood pressure (systolic blood pressure higher than 174 or diastolic blood pressure higher than 104 mm Hg) having a history of liver disease having a history of hyperparathyroidism pregnancy and/or lactation Reproductive-aged women (under 50 years old) who are not receiving adequate contraception consuming nutritional supplement containing vitamin D from 2 months ago
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum 25(OH)D concentration. Timepoint: baseline and 8 weeks after intervention. Method of measurement: measurement of serum level of 25OHD. | — |
Secondary
| Measure | Time frame |
|---|---|
| Proinflammatory biomarkers. Timepoint: baseline and 8 weeks after intervention. Method of measurement: measurement of serum hs-CRP, IL-6, IL-1ß concentrations.;Bone biomarker. Timepoint: baseline and 8 weeks after intervention. Method of measurement: measurement of serum parathormone concentration.;Some neurotransmitters involved in depression. Timepoint: baseline and 8 weeks after intervention. Method of measurement: measurement of serum oxytocin and platelet serotonin concentrations.;Depression status. Timepoint: baseline and 8 weeks after intervention. Method of measurement: Using Beck questioner. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMina Kaviani
Islamic Azad University
Outcome results
None listed