Psoriasis. psoriasis vulgaris
Conditions
Interventions
Intervention 1: Intervention group: taking capsules containing 300 mg of Ursudocysical colic acid once a day for six months. Intervention 2: control group: taking placebo as a capsule of 300 mg once a
Treatment - Drugs
Placebo
Intervention group: taking capsules containing 300 mg of Ursudocysical colic acid once a day for six months
control group: taking placebo as a capsule of 300 mg once a day
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients with psoriasis who are candidated for systemic therapy; they have not received systemic therapy as well as phtotherapy for their disease during the past 6 month; they have not received topical treatment over the past month. Exclusion criteria: patients with history of heart failure, hepatic, renal and pulmonary disease or icreasement in liver function tests(More than 1.5 times normal), diabetes mellitus and other serious systemic disease; pregnant women; since the efficacy and safety of using Uroseodocyclic acid in the pediatric population has not been established, this group will also be excluded from the study; People with a history of biliary disorders, and hypersensitivity to bile acids
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Psoriasis area and severity index. Timepoint: Before intervention, two months after the intervention, six months after the intervention. Method of measurement: FotoFinder PASIvision.;Dermatology Life Quality Index. Timepoint: Before intervention, two months after the intervention, six months after the intervention. Method of measurement: Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver enzymes. Timepoint: Before intervention, two months after the intervention, six months after the intervention. Method of measurement: lab tests.;Serum lipid level. Timepoint: Before intervention, two months after the intervention, six months after the intervention. Method of measurement: lab tests.;Fatty liver. Timepoint: Before intervention, two months after the intervention, six months after the intervention. Method of measurement: Sonography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Amine Kashiri
Tehran University of Medical Sciences
Outcome results
None listed