Acute Myocardial Infarction. Acute myocardial infarction
Conditions
Interventions
Intervention 1: Intervention group: Group 1: Patients who have a stent after thrombosuction. Intervention 2: Intervention group:Group 2: Patients who receive 180 microgram per kilogram of intracoronar
Treatment - Drugs
Intervention group: Group 1: Patients who have a stent after thrombosuction.
Intervention group:Group 2: Patients who receive 180 microgram per kilogram of intracoronary bolus eptifibatide by interval of 10 minutes and then stent is embeded.
Intervention group:Group 3: Patients who receive 6 mg of intra-coronary reptal after thrombosis, and then inserted into the stent.
Intervention group: Group 4:Patients after thrombosuction will receive 180 microgram per kilogram of intravenous bolus eptifibatide and then receive 2 microgram per kilogram per minute of infusion ove
Sponsors
Rasht University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: ischemic tipic chest pain extending more than 30 min, STelevation more than 1 mm in at least 2 leads with the same name, all patients with STEMI candidate for primary PCI, myocardial infarction not extending more than 12 hours, having life expectancy not less than 6 months, consent for participation in the study, age 18 to 80 years, no evidence for prior myocardial infarction, not having contraindications for reteplase or eptifibatide, not having left bundle branch block, not using GPIIb/IIIa in recent two weeks.
Exclusion criteria
Exclusion criteria: rescue PCI after thrombolytic therapy, emergency CABG, cardiogenic shock, atrial fibrillation TIMI flow grade 3 in primary angiography(ie, having normal blood flow in coronary arteries) simultaneously presence in another intervention study
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Left ventricular diastolic dysfunction change. Timepoint: before and after angiography. Method of measurement: according to echocardiographic criteria.;ST resolution average. Timepoint: before and 90 minutes after PCI. Method of measurement: based on electrocardiogram.;Average of EF changes. Timepoint: before and 3 to 4 days after angioplasty. Method of measurement: based on echocardiography. | — |
Primary
| Measure | Time frame |
|---|---|
| Coronary blood flow. Timepoint: before and after primary PCI. Method of measurement: based on angiographic scale TIMI blush grade. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMostafa Zadkamali
Rasht University of Medical Sciences
Outcome results
None listed