Comparison of the prophylactic effect of Dexamethasone and Ondansetron versus placebo on pruritus due to intrathecal Sufentanil in painless labor

Comparison of the prophylactic effect of Dexamethasone and Ondansetron versus placebo on pruritus due to intrathecal Sufentanil in painless labor: a double blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201709249014N189

Enrollment

Registered

2017-10-02

Start date

2016-12-30

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pruritus. Pruritus

Interventions

Intervention 1: Intervention group 1: Intravenous injection of 2 ml Ondansetron (4 mg) single dose before labor. Intervention 2: Intervention group 2: Intravenous injection of 2 ml Dexamethasone (8 mg

Treatment - Drugs

Placebo

Intervention group 1: Intravenous injection of 2 ml Ondansetron (4 mg) single dose before labor.

Intervention group 2: Intravenous injection of 2 ml Dexamethasone (8 mg) single dose before labor.

Control group: Intravenous injection of 2 ml distilled water single dose before labor.

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age of 18 to 45 years; pregnant woman; prim gravida; gestational age of 30 to 40 weeks; enter active phase of labor. Exclusion criteria: Need to emergency cesarean section; sensitivity to Ondansetron or Dexamethasone.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Assessing pruritus. Timepoint: every 15 minutes until labor. Method of measurement: Using Visual Analog Scale (VAS).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZeinab Ghanbari

Fatemieh Hospital

zeynab7001@yahoo.com+98 81 3828 3939

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026