Effect of topical cefazolin on reducing cesarean section infection

Effectiveness of topical cefazolin solution versus normal saline in reducing cesarean section infection

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017092436376N1

Enrollment

108

Registered

2017-10-23

Start date

2017-09-27

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infection Caesarean section. Infection of obstetric surgical wound

Interventions

Intervention 1: First group (intervention): Immediately after sewing the fascia, a venous Cefazolin 1000 mg vial with 300 ml of normal saline was washed. Intervention 2: Second group (intervention): I

Treatment - Drugs

Placebo

First group (intervention): Immediately after sewing the fascia, a venous Cefazolin 1000 mg vial with 300 ml of normal saline was washed.

Second group (intervention): Immediately after sewing the fascia with 300 cc normal saline was washed.

Third group (control): No washing is done (routine method).

Eligibility

Sex/Gender

Female

Age

17 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: women; Gestational age; Having a living and single fetus; Absence of underlying illness; Classic cesarean section (van Steele); Lack of rupture of the Amniotic sac Exclusion criteria: Women under the age of 18 and over 40 years; Gestational age below 37 weeks; Stillbirth; History of underlying disease; Addiction; Recent antibiotic use; bleeding more than usual during cesarean section; non-classic cesarean sections; Rupture of the Amniotic sac longer than 18 hours

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Redness. Timepoint: Days 5 and 10. Method of measurement: Red spot on both sides of the wound.;Edama. Timepoint: Days 5 and 10. Method of measurement: Check swelling of the wound and measure to cm.;Ecchymosis. Timepoint: Days 5 and 10. Method of measurement: Check ecchymosis of the wound and measure to cm.;Discharge. Timepoint: Days 5 and 10. Method of measurement: observation.;Approximation. Timepoint: Days 5 and 10. Method of measurement: observation.	—

Measure

Time frame

Redness. Timepoint: Days 5 and 10. Method of measurement: Red spot on both sides of the wound.;Edama. Timepoint: Days 5 and 10. Method of measurement: Check swelling of the wound and measure to cm.;Ecchymosis. Timepoint: Days 5 and 10. Method of measurement: Check ecchymosis of the wound and measure to cm.;Discharge. Timepoint: Days 5 and 10. Method of measurement: observation.;Approximation. Timepoint: Days 5 and 10. Method of measurement: observation.

—

Secondary

Measure	Time frame
Pain. Timepoint: Days 1, 5 and 10. Method of measurement: Measuring the severity of pain based on fatigue from 1 to 5.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBehnaz Soeezi

Sabzevar University of Medical Sciences

Behnazsovizi1355@gmail.com+98 51 4401 1000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026