Type 2 diabetes mellitus. Non-insulin-dependent diabetes mellitus
Conditions
Interventions
Treatment - Drugs
Placebo
Intervention group: Taking orally 2 herbal capsules of 350 mg mellissa officinalis extract per day ( one after Lunch and one after Dinner) for 3 months. Capsules are provided in Institute of Medicinal
Placebo group: Taking orally 2 similar capsules of toasted flour per day for 3 months
Sponsors
private
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria are: getting at least 11 scores in the Beck Depression Inventory (BDI-II); Patients aged 20 to 65 years for both sexes; The body mass index less than 35 kg/m2; no pregnancy or lactation; triglycerides less than 400 mg/dl; HbA1c < % 8; using a common diabetes drug (metformin and glibenclamide). Exclusion criteria are: Lack of any co-disorders including cardiovascular, liver, renal, allergic and infectious diseases as well as thyroid disorders and glaucoma; taking non steroidal anti-inflammatory drugs (NSAIDS), anti depression or estrogen and progesterone.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sleep quality. Timepoint: Before the experiment and 12 weeks after intervention. Method of measurement: Pittsburgh Sleep Quality Index.;Depression. Timepoint: Before the experiment and 12 weeks after intervention. Method of measurement: Beck Depression Questionnaire.;FBS. Timepoint: Before the experiment and 12 weeks after intervention. Method of measurement: Enzymatic method.;Hs-CRP. Timepoint: Before the experiment and 12 weeks after intervention. Method of measurement: ELISA.;Anxiety. Timepoint: Before the experiment and 12 weeks after intervention. Method of measurement: Beck Anxiety Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| BP. Timepoint: Before the experiment and 12 weeks after intervention. Method of measurement: Digital sphygmomanometer.;Body mass index. Timepoint: Before the experiment and 12 weeks after intervention. Method of measurement: Weight (kg) /height2 (m2).;Weight. Timepoint: Before the experiment and 12 weeks after intervention. Method of measurement: Seca scale.;Waist circumference. Timepoint: Before the experiment and 12 weeks after intervention. Method of measurement: Elastic tape.;Physical activity. Timepoint: Before intervention and 6 and 12 weeks after intervention. Method of measurement: International Physical Activity Questionarre.;Energy intake. Timepoint: Before intervention and 6 and 12 weeks after intervention. Method of measurement: 24-hour dietary recall. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMostafa Safari
Iran University Medical of Scienses
Outcome results
None listed