Modification of Complications in Infertile Men with Varicocele by Curcumin Nanomicels

Effect of Curcumin Nanomicelle on Semen Parameters, Oxidative Stress, and Reproductive Hormones in Varicocele Men

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170923036334N3

Enrollment

100

Registered

2022-05-07

Start date

2022-04-21

Completion date

Unknown

Last updated

2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Varicocele. Scrotal varices

Interventions

Intervention 1: Intervention Group:In the Intervention Group of Varicocele Patients Who were Treated with Nano-micelles Curcumin 80 mg Daily for 10 Weeks, Serum and Semen Samples were Taken from them

Eligibility

Sex/Gender

Male

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Infertile Men with Varicocele

Exclusion criteria

Exclusion criteria:

Design outcomes

Secondary

Measure	Time frame
Viability. Timepoint: Before Taking the Drug and 10 Weeks After Taking the Drug. Method of measurement: Viability is Assessed by Eosin-Nigrosin Staining and Examined Using a Light Microscope.;DNA Damage Assessment. Timepoint: Before Taking the Drug and 10 Weeks After Taking the Drug. Method of measurement: Tunnel Kit.;Measurement of Sperm Mitochondrial Activity. Timepoint: Before Taking the Drug and 10 Weeks After Taking the Drug. Method of measurement: Rhodamine Staining is Used to Assess the Mitochondrial Activity of Sperm.	—

Measure

Time frame

Viability. Timepoint: Before Taking the Drug and 10 Weeks After Taking the Drug. Method of measurement: Viability is Assessed by Eosin-Nigrosin Staining and Examined Using a Light Microscope.;DNA Damage Assessment. Timepoint: Before Taking the Drug and 10 Weeks After Taking the Drug. Method of measurement: Tunnel Kit.;Measurement of Sperm Mitochondrial Activity. Timepoint: Before Taking the Drug and 10 Weeks After Taking the Drug. Method of measurement: Rhodamine Staining is Used to Assess the Mitochondrial Activity of Sperm.

—

Primary

Measure	Time frame
Serum Levels of Sex Hormones. Timepoint: Before Taking the Drug and 10 Weeks After Taking the Drug. Method of measurement: Eliza Kit.;Sperm Parameters. Timepoint: Before Taking the Drug and 10 Weeks After Taking the Drug. Method of measurement: Standard Clinical Analysis of Semen for Evaluation of Sperm Parameters with The Usual Laboratory Method and Light Microscope According to the Organization CriteriaWHO-2010 World Health Takes Place.;Oxidative Stress Rate. Timepoint: Before Taking the Drug and 10 Weeks After Taking the Drug. Method of measurement: ROS Positive Sperms were Evaluated Using H2DCFDA (DCFH - DA: 2 ', 7'-dichlorodihydrofluoresceindiacetat) (Sigma Co., USA) and Analyzed by Flow Cytometry.	—

Measure

Time frame

Serum Levels of Sex Hormones. Timepoint: Before Taking the Drug and 10 Weeks After Taking the Drug. Method of measurement: Eliza Kit.;Sperm Parameters. Timepoint: Before Taking the Drug and 10 Weeks After Taking the Drug. Method of measurement: Standard Clinical Analysis of Semen for Evaluation of Sperm Parameters with The Usual Laboratory Method and Light Microscope According to the Organization CriteriaWHO-2010 World Health Takes Place.;Oxidative Stress Rate. Timepoint: Before Taking the Drug and 10 Weeks After Taking the Drug. Method of measurement: ROS Positive Sperms were Evaluated Using H2DCFDA (DCFH - DA: 2 ', 7'-dichlorodihydrofluoresceindiacetat) (Sigma Co., USA) and Analyzed by Flow Cytometry.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAtefeh Verdi

Iranian academic center for education culture and research

Atefeh.Verdi@yahoo.com+98 25 3270 0155

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026