The therapeutic effect of tamsulosin and tadalafil in stone expulsion of patients with ureteral stones

A comparative study on the therapeutic effect of tamsulosin, tadalafil and placebo in stone expulsion of patients with distal ureteral stones

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201709191853N14

Enrollment

132

Registered

2017-11-20

Start date

2017-11-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ureter stone. Calculus of ureter

Interventions

Intervention 1: Tamsulosin capsule with a dose of 0.4 mg made in Iran, one daily for a maximum of 4 weeks. Intervention 2: Tadalafil tablets with a dose of 10 mg in capsule cover made in Iran, one da

Treatment - Drugs

Tamsulosin capsule with a dose of 0.4 mg made in Iran, one daily for a maximum of 4 weeks

Tadalafil tablets with a dose of 10 mg in capsule cover made in Iran, one daily for a maximum of 4 weeks

Placebo capsule made in Iran, one daily for a maximum of 4 weeks

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients 18-65 years of age; individual dilated ureteral stone with a size smaller than 10mm lower than Common Illiac vascular by contrast-free CT scan; patients whose colic with a single dose of diclofenac (100mg oral or suppository) and, if not recovered, with a single dose of pethidine (50mg intravenous) in one day is improved. Exclusion criteria: Fever; patients with GFR <30; single kidney; multiple ureteral stones; history of endoscopic surgery or open surgery in the urinary tract; diabetes; gastric ulcer; concomitant treatment with alpha-blockers, calcium or nitrate antagonists; pregnant or lactating mothers; any allergic reaction to drugs used; patients requiring surgical or endoscopic intervention following non-pain relief during drug intervention (resistant colic); uremic symptoms; urinary retention; patients who have an urge to receive immediate medical intervention.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Stone expulsion. Timepoint: 2 and 4 weeks after intervention. Method of measurement: Stone expulsion by patient's observation, CT scan without contrast in case of not observing stone expulsion.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Ardalan Akhavan

Urology Research Center, Guilan University of Medical Sciences

urc1384@yahoo.com+98 13 3352 5259

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026