The effect of using HCG in combination with the GnRh agonist for improving IVF outcomes

Comparing the outcomes of dual trigger with GnRh agonist along with HCG versus HCG alone in normal responder patients in antagonist ART protocol

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017091736235N1

Enrollment

164

Registered

2017-11-05

Start date

2017-10-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infertility. female infertility

Interventions

Intervention 1: Control group will receive 10000 unit HCG for triggering final oocyte maturation. Intervention 2: Intervention group will receive 10000 unit HCG pluse 0.2 mg decapeptyle for final mat

Treatment - Drugs

Control group will receive 10000 unit HCG for triggering final oocyte maturation

Intervention group will receive 10000 unit HCG pluse 0.2 mg decapeptyle for final maturation of oocyte

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Infertility due to male factor, tubal factor or unexplained; IVF less than 2 times; age between 18 and 40; BMI between 18 and 30; normal PRL and TSH; FSH less than 10; The minimum sperm count, 10 million and the minimum 3% of the sperms should have normal morphology. Exclusion criteria: AFC more than 15; E2 more than 3000 at trigger day or AFC more than 20; sensitization to HCG or gonadotropins; FSH more than 10 at third day of cycles or AFC less than 5; AUB; documented uterine anomaly in hysterogram or HSG; endometriosis (grade 3 and 4); Diabetes or uncontrolled HTN, kidney or liver dysfunction; PCO; Cancer, tumor, or pituitary adenoma; Ovarian cysts; hydrosalpinx; intramural or submucosal myoma larger than 6cm

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Clinical pregnancy. Timepoint: 28 days after transfer. Method of measurement: vaginal sonography.	—

Secondary

Measure	Time frame
Chemical pregnancy rate. Timepoint: 14 days after transfer. Method of measurement: BHCG test.;Number of embryo formation. Timepoint: 3 days after pancture. Method of measurement: Number.;OHSS. Timepoint: Till 2 weeks after ET. Method of measurement: sonography and symptoms.;Abortion. Timepoint: 6th and 12th week of pregnancy. Method of measurement: sonography.;Number of oocyte (2PN). Timepoint: Puncture day. Method of measurement: Number.	—

Measure

Time frame

Chemical pregnancy rate. Timepoint: 14 days after transfer. Method of measurement: BHCG test.;Number of embryo formation. Timepoint: 3 days after pancture. Method of measurement: Number.;OHSS. Timepoint: Till 2 weeks after ET. Method of measurement: sonography and symptoms.;Abortion. Timepoint: 6th and 12th week of pregnancy. Method of measurement: sonography.;Number of oocyte (2PN). Timepoint: Puncture day. Method of measurement: Number.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Sara Mokhtar

Avicenna Infertility And Recurrent Abortion Research Institute

Smkhtr@yahoo.com+98 21 23519

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026