Oligohydramnios. Oligohydramnios
Conditions
Interventions
Intervention 1: Intervention group: oral sildenafil tablets with a dose of 25 mg every 8 hours along with hydration therapy. Intervention 2: Control group: Hydration therapy alone.
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: singleton pregnancy Gestational age 28 weeks and above Ultrasonically diagnosed oligohydramnios in the third trimester ( defined as Amniotic Fluid Index (AFI) blow 8 cm )
Exclusion criteria
Exclusion criteria: Intrauterine growth restriction (IUGR) Fetal Anomaly Abnormal Blood Flow Patterns by Color Doppler flow imaging Abnormal NST Treatment with Prostaglandin synthetase inhibitors Rupture of membranes Active Labor Chronic Hypertension Overt Diabetes Mellitus Maternal Hydration therapy contraindications ( like renal, respiratory or cardiac diseases )
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amniotic fluid index. Timepoint: 24 hours after starting treatment and every week after discharge for up to 6 weeks. Method of measurement: Ultrasonography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of intervention until delivery. Timepoint: During intervention. Method of measurement: check list.;Infant weight. Timepoint: At the end of the study. Method of measurement: Balance (in kilograms and grams).;NICU Admission. Timepoint: At the end of the study. Method of measurement: File information.;APGAR Score. Timepoint: At the end of the study. Method of measurement: File information.;Type of delivery. Timepoint: At the end of the study. Method of measurement: File information.;Gestational Age at birth. Timepoint: At the end of the study. Method of measurement: File information. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contact?Dr Mahbobeh Mesgaran
Arash Wamen's Hospital
Outcome results
None listed