Effects of topical erythropoietin gel on non-surgical treatment of chronic periodontitis

Effects of topical erythropoietin gel on non-surgical treatment of chronic periodontitis: a split mouth randomized clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017091636203N1

Enrollment

Registered

2017-11-06

Start date

2017-09-16

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic periodontitis. chronic periodontitis

Interventions

Intervention 1: In test group after measusing the parameters , SRP will be done.Then a complex of 1cc of EPO gel(4000IU) and 1 cc of carboxymethyl cellulose gel will be applied in the site for 5 times

Treatment - Drugs

In test group after measusing the parameters , SRP will be done.Then a complex of 1cc of EPO gel(4000IU) and 1 cc of carboxymethyl cellulose gel will be applied in the site for 5 times durin 2 weeks.

In control group after measusing the parameters , SRP will be done.Then 2 cc of carboxymethyl cellulose gel will be applied in the site for 5 times durin 2 weeks.

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age>18; No SRP during last 6 monthes; at least 2 cross arch teeth with more than 5mm probing depth. Exclusion criteria: Patients whit uncontrolled systemic disease(diabetes mellitus, cancer,heart disease); Systemic antibiotics taken within previous 2 months; Enrollment in an other clinical trials; Current smokers; Patients with aggressive or narcotizing types of periodontitis.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Probing Depth. Timepoint: Before SRP and after months. Method of measurement: By UNC-15 probe.;Clinical Attachment Level. Timepoint: Before SRP and after3 monthes. Method of measurement: UNC-15 probe.;Bleeding On Probing. Timepoint: Before SRP and after monthes. Method of measurement: Sulcular bleeding index (muhleman).;Gingival index. Timepoint: Before SRP and after3 monthes. Method of measurement: By observation. no inflamation=0 mild inflamation and color change which doesnt involve papilla=1, inflamation like group 1 which involves papilla=2 shine and redness and inflamation at margin or papilla=3.;Plaque Index. Timepoint: Before SRP and after3 monthes. Method of measurement: By moving prob on tooth surface, no plaque=0, plaque in cervical1/3 only recognizable by prob =1, plaque in cervial1/3 reconizable by abservation=2.	—

Measure

Time frame

Probing Depth. Timepoint: Before SRP and after months. Method of measurement: By UNC-15 probe.;Clinical Attachment Level. Timepoint: Before SRP and after3 monthes. Method of measurement: UNC-15 probe.;Bleeding On Probing. Timepoint: Before SRP and after monthes. Method of measurement: Sulcular bleeding index (muhleman).;Gingival index. Timepoint: Before SRP and after3 monthes. Method of measurement: By observation. no inflamation=0 mild inflamation and color change which doesnt involve papilla=1, inflamation like group 1 which involves papilla=2 shine and redness and inflamation at margin or papilla=3.;Plaque Index. Timepoint: Before SRP and after3 monthes. Method of measurement: By moving prob on tooth surface, no plaque=0, plaque in cervical1/3 only recognizable by prob =1, plaque in cervial1/3 reconizable by abservation=2.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahsa Vafaei

Dental School Of Tehran University Of Medical Sciences

mahsa.vafaei22@gmail.com+98 21 4608 5883

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026