Impact of Nanosil and Chlorhexidine on ventilator associated pneumonia

The comparision of the impact of Nanosil and Chlorhexidine mouthwashes in an oral decontamination plan on the occurrence of ventilator associated pneumonia in hospitalized patients in the intensive care unit

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017091636194N1

Enrollment

Registered

2017-10-07

Start date

2016-10-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator Associated Pneumonia. Pneumonia organism unspecified

Interventions

Intervention 1: Intervention group: During a five day period, using ten milliliters of Nanosil mouthwash(made in Iran, Kimiafam pharmaceutical company), oral care and decontamination will be performed

Prevention

Intervention group: During a five day period, using ten milliliters of Nanosil mouthwash(made in Iran, Kimiafam pharmaceutical company), oral care and decontamination will be performed for the experim

Control group: During a five day period, using ten milliliters of Chlorhexidine mouthwash%0.12(made in Iran, Behsa company), oral care and decontamination will be performed for the experimental group

Eligibility

Sex/Gender

All

Age

17 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: aged between 18 and 70 years old; no clear maxillofacial trauma; having tracheal tube, locating the patient under the mechanical ventilator; no pneumonia or previous respiratory infections; utmost 48 hours have passed since the onset of intubation; no ban and having no alergia on using mouthwash; Exclusion criteria: death before the end of intervention; extubation before the end of intervention; transfer the patient to other wards or hospital among the intervention; other diagnostic or therapeutic procedure on mouth and pharynx or trashea.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Occurance of ventilator associated pneumonia. Timepoint: First day and fifth day. Method of measurement: Standard modified clinical pulmonary infection score.	—

Secondary

Measure	Time frame
Degree of dysfunction of organs and prediction of mortality. Timepoint: First day and fifth day. Method of measurement: Standard sepsis related organ failure assessment tool.;Degree of consciousness. Timepoint: First day and fifth day. Method of measurement: Standard glascow coma scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBahareh Khaky

Isfahan University of Medical Sciences

bahar.khaky@gmail.com+98 31 3440 8382

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026