study of the effects of apple syrup and barberry syrup on chemotherapy-induced nausea and vomiting

Study of the effects of apple (Malus domestica) syrup and barberry (Berberis orietalis) syrup on chemotherapy-induced nausea and vomiting

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201709142027N10

Enrollment

Registered

2017-09-27

Start date

2017-04-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chemotherapy-induced nausea and vomiting. Drugs, medicaments and biological substances causing adverse effects in therapeutic use

Interventions

Intervention 1: barberry syrup 34.75% 1 day before chemotherapy to 6 days after chemotherapy, 10 ml of syrup Three times daily. Intervention 2: Apple syrup 20% 1 day before chemotherapy to 6 days afte

Treatment - Drugs

Placebo

barberry syrup 34.75% 1 day before chemotherapy to 6 days after chemotherapy, 10 ml of syrup Three times daily

Apple syrup 20% 1 day before chemotherapy to 6 days after chemotherapy, 10 ml of syrupTDS daily

Placebo syrup 1 day before chemotherapy to 6 days after chemotherapy, 10 ml of syrupTDS daily

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion criteria: The patients older than 18 years; with diagnosed cancer that experienced nausea and vomiting during the previous cycle of chemotherapy who received the same chemotherapy and anti-emetic regime with previous chemotherapy cycle at the time of enrollment in the study Exclusion criteria: Uncontrolled Diabetes Mellitus; Changes in chemotherapy regime; Having other clinical conditions that cause nausea and vomiting such as brain metastasis.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Incidence of nausea. Timepoint: 24 hours after chemotherapy. Method of measurement: Patients questionnaire based on MASCC/ESMO Antiemetic Guidelines.;Incidence of vomiting. Timepoint: 24 hours after chemotherapy. Method of measurement: Patients questionnaire based on MASCC/ESMO Antiemetic Guidelines.	—

Secondary

Measure	Time frame
Severity of nausea. Timepoint: 1 day before chemotherapy to 6 days after chemotherapy. Method of measurement: Patients questionnaire based on MASCC/ESMO Antiemetic Guidelines.;Severity of vomiting. Timepoint: 1 day before chemotherapy to 6 days after chemotherapy. Method of measurement: Patients questionnaire based on MASCC/ESMO Antiemetic Guidelines.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactEbrahim Salehifar

Faculty of Pharmacy, Mazandaran University of Medical Sciences

Esalehifar@Mazums.ac.ir+98 11 3354 3082

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026