Pulmonary infection Caused by Ventilator. Pulmonary mycobacterial infection
Conditions
Interventions
Intervention 1: In treatment group, patients received administrated 150 mg of intravenous colistin in addition to 1000000 units inhaled colistin for one week every eight hours. Intervention 2: The con
Treatment - Drugs
In treatment group, patients received administrated 150 mg of intravenous colistin in addition to 1000000 units inhaled colistin for one week every eight hours.
The control group only received 300 mg of colistin every eight hours intravenously for one week.
Sponsors
Vice chancellor for Research and Technology of Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
16 Years to 100 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: age ranging: over 16 years; multi-drug resistant patients especially multidrug-resistant Acinetobacter; without sensitivity to polymyxins; positive culture (Colony count: BAL 104 or Mini BAL 105). Exclusion criteria: patient death; incidence of sensitivity to polymyxins; reduced GFR <0.25; incidence of bronchospasm evidences in treatment group.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The severity of pulmonary infection using CPIS. Timepoint: At the first, third and seventh days after intervention. Method of measurement: Using Clinical Pulmonary Infection Score (CPIS) Calculator; CPIS more than 6 at baseline or at 72 h: pneumonia; CPIS less or equal to 6 at 72 hours patient: without pneumonia. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Behnam Mahmoudyeh
Arak University of Medical sciences , Iran
Outcome results
None listed