Effects of dexmedetomidine drug in heart surgery

Studying the effects of dexmedetomidine on clinical outcomes and renal function after heart surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170912036157N1

Enrollment

Registered

2019-07-30

Start date

2017-03-20

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Coronary artery bypass grafting. Condition 2: Aneurysms of the cardiac arteries. Coronary artery aneurysm and dissection Aortic aneurysm and dissection

Interventions

Intervention 1: Intervention group: High-dose Pfizer company dexmedetomidine (0.75 ug/kg/hr) once from anesthesia induction till the end of operation. Intervention 2: Control group: Low dose Pfizer c

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Informed consent for participation Elective open heart surgery on cardiopulmonary bypass Age over 18 years

Exclusion criteria

Exclusion criteria: Background of preexisting inflammatory disease history of preexisting renal insufficiency or severe renal disease before operation

Design outcomes

Primary

Measure	Time frame
Systolic blood pressure. Timepoint: Before operation and 6, 12, 24 and 48 hours after operation. Method of measurement: Vital sign monitoring system.;Urine output. Timepoint: During cardiopulmonary bypass and 24 and 48 hours after transfer to intensive care unit. Method of measurement: Urine volume measurement.;Blood urea nitrogen (BUN). Timepoint: Before operation and 24, 48 and 72 hours after operation. Method of measurement: Auto-analyzer.;Mechanical ventilation time. Timepoint: During operation and intensive care unit stay. Method of measurement: Recording the time.;Blood and blood products transfusion. Timepoint: In operation room and 48 hours after operation. Method of measurement: Recording the amount received.;Inotrope medicines. Timepoint: In the operation room and until 48 hours post-operation. Method of measurement: Recording the administered amount.;Diuretics. Timepoint: In the operation room and intensive care unit. Method of measurement: Recording the administered amounts.;Systolic blood pressure. Timepoint: Before operation and 6, 12, 24 and 48 hours after operation. Method of measurement: Vital sign monitoring system.;Mean arterial blood pressure. Timepoint: Before operation and 6, 12, 24 and 48 hours after operation. Method of measurement: Vital sign monitoring system.;Creatinine. Timepoint: Before operation and 24, 48 and 72 hours after operation. Method of measurement: Auto-analyzer.;Intensive care unit (ICU) stay. Timepoint: During Intensive care unit (ICU) stay. Method of measurement: Recording the time.;Operation time. Timepoint: During operation. Method of measurement: Recording the time.;Cardiopulmonary bypass (CPB) duration. Timepoint: During CPB. Method of measurement: Recording the time.	—

Measure

Time frame

Systolic blood pressure. Timepoint: Before operation and 6, 12, 24 and 48 hours after operation. Method of measurement: Vital sign monitoring system.;Urine output. Timepoint: During cardiopulmonary bypass and 24 and 48 hours after transfer to intensive care unit. Method of measurement: Urine volume measurement.;Blood urea nitrogen (BUN). Timepoint: Before operation and 24, 48 and 72 hours after operation. Method of measurement: Auto-analyzer.;Mechanical ventilation time. Timepoint: During operation and intensive care unit stay. Method of measurement: Recording the time.;Blood and blood products transfusion. Timepoint: In operation room and 48 hours after operation. Method of measurement: Recording the amount received.;Inotrope medicines. Timepoint: In the operation room and until 48 hours post-operation. Method of measurement: Recording the administered amount.;Diuretics. Timepoint: In the operation room and intensive care unit. Method of measurement: Recording the administered amounts.;Systolic blood pressure. Timepoint: Before operation and 6, 12, 24 and 48 hours after operation. Method of measurement: Vital sign monitoring system.;Mean arterial blood pressure. Timepoint: Before operation and 6, 12, 24 and 48 hours after operation. Method of measurement: Vital sign monitoring system.;Creatinine. Timepoint: Before operation and 24, 48 and 72 hours after operation. Method of measurement: Auto-analyzer.;Intensive care unit (ICU) stay. Timepoint: During Intensive care unit (ICU) stay. Method of measurement: Recording the time.;Operation time. Timepoint: During operation. Method of measurement: Recording the time.;Cardiopulmonary bypass (CPB) duration. Timepoint: During CPB. Method of measurement: Recording the time.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactZiae Totonchi

Rajaie Cardiovascular Medical and Research Center

ziya189@yahoo.com+98 21 2392 4714

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026