Efficacy of Paracetamol in treatment of patent dactus arteriosus in neonates

Efficacy of Paracetamol versus Ibuprofen for the treatment of patent ductus arteriosus in neonates

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170910036112N2

Enrollment

Registered

2018-03-04

Start date

2017-09-11

Completion date

Unknown

Last updated

2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patent ductus arteriosus in neonate. Patent Ductus Arteriosus

Interventions

Intervention 1: Intervention group 2: Oral Ibuprofen 10mg/kg/dose for first day and 5mg/kg/dose for second and third day. Intervention 2: Intervention group 1: Intra venous Paracetamol 15mg/kg/dose ev

Eligibility

Sex/Gender

All

Age

3 Days to 7 Days

Inclusion criteria

Inclusion criteria: All neonates with post natal age more than 3 days with hemodynamically significant PDA; Acceptance of inform consent by parents.

Exclusion criteria

Exclusion criteria: All congenital heart diseases other than PDA Contraindication of using ibuprofen or acetaminophen Persistence fetal circulation (PFC)

Design outcomes

Primary

Measure	Time frame
Closure of PDA in neonate. Timepoint: 72 hours after birth and after 3 days of therapy initiation (therapy completion). Method of measurement: Echocardiography.	—

Secondary

Measure	Time frame
_. Timepoint: _. Method of measurement: _.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Sima Safaei

Kashan University of Medical Scienses

sima_safa@yahoo.com+93 155540026

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026