The effect of ozone on the lumbar disc herniation using magnetic resonance imaging findings

Comparison of magnetic resonance imaging (MRI) findings before and after intradiscal ozone injection in patients with lumbar disc herniation

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170910036107N3

Enrollment

Registered

2019-01-27

Start date

2018-12-26

Completion date

Unknown

Last updated

2019-02-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lumbar disc herniation. Thoracic, thoracolumbar, and lumbosacral intervertebral disc disorders

Interventions

Intervention group: Intradiscal and intraforaminal injection of 10 cc of ozone (mixture of o2-o3) at a concentration of 30 µg/ml under fluoroscope guide with the paravertebral approach for one sessi

Eligibility

Sex/Gender

All

Age

20 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients with lumbar pain due to disc herniation with any intensity Proven lumbar disk herniation using magnetic resonance imaging (MRI)

Exclusion criteria

Exclusion criteria: History of lumbar disc herniation for more than 2 months Previous lumbar disc interventions, including surgery Ozone injection contraindications such as G6PD deficiency, uncontrolled hyperthyroidism, pregnancy, and leukemia

Design outcomes

Primary

Measure	Time frame
Type of lumbar disc herniation. Timepoint: Before intervention and 6 months after intervention. Method of measurement: Magnetic resonance imaging (MRI).;Grade of disc degeneration. Timepoint: Before intervention and 6 months after intervention. Method of measurement: Magnetic resonance imaging (MRI).;Location of lumbar disc herniation. Timepoint: Before intervention and 6 months after intervention. Method of measurement: Magnetic resonance imaging (MRI).;Grade of nerve root compression. Timepoint: Before intervention and 6 months after intervention. Method of measurement: Magnetic resonance imaging (MRI).;Grade of central spinal canal stenosis. Timepoint: Before intervention and 6 months after intervention. Method of measurement: Magnetic resonance imaging (MRI).;Grade of neuroforaminal stenosis. Timepoint: Before intervention and 6 months after intervention. Method of measurement: Magnetic resonance imaging (MRI).	—

Measure

Time frame

Type of lumbar disc herniation. Timepoint: Before intervention and 6 months after intervention. Method of measurement: Magnetic resonance imaging (MRI).;Grade of disc degeneration. Timepoint: Before intervention and 6 months after intervention. Method of measurement: Magnetic resonance imaging (MRI).;Location of lumbar disc herniation. Timepoint: Before intervention and 6 months after intervention. Method of measurement: Magnetic resonance imaging (MRI).;Grade of nerve root compression. Timepoint: Before intervention and 6 months after intervention. Method of measurement: Magnetic resonance imaging (MRI).;Grade of central spinal canal stenosis. Timepoint: Before intervention and 6 months after intervention. Method of measurement: Magnetic resonance imaging (MRI).;Grade of neuroforaminal stenosis. Timepoint: Before intervention and 6 months after intervention. Method of measurement: Magnetic resonance imaging (MRI).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactPayam Ghaderi

Tabriz University of Medical Sciences

Ghaderi.payam@gmail.com+98 41 3333 2803

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026