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Effect of treatment with tissue plasminogen activator in improving clinical status of patients with acute ischemic stroke

Effect of treatment with tissue plasminogen activator in improving clinical status of patients with acute ischemic stroke: a randomized clinical trial

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT201709049014N182
Enrollment
40
Registered
2017-09-09
Start date
2017-09-23
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute ischemic stroke. Cerebral infarction, unspecified

Interventions

Intervention 1: Intervention group: Routine treatment plus tissue plasminogen activator 0.9 mg/kg through intravenous infusion. Intervention 2: Control group: Just routine treatment.
Treatment - Drugs
Intervention group: Routine treatment plus tissue plasminogen activator 0.9 mg/kg through intravenous infusion.

Sponsors

Vice-chancellor for Research and Technology, Hamadan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 85 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age of 18 to 85 years; acute ischemic stroke. Exclusion criteria: A history of acute ischemic stroke in the past 3 months; using heparin or warfarin in the past 48 hours; a history of head trauma in the past 3 months; a history of intra cranial hemorrhage; a history of myocardial infarction in the past 3 months; gastric hemorrhage in the past 3 months; a history of major surgery in the past 2 weeks; a history of convulsion.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Assessing the neurological signs. Timepoint: every 12 hours for 72 hours. Method of measurement: using NIHSS scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Ghadimi Farah

Sina Hospital

aghf@ymail.com+98 81 3827 4184

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026