Comparison of the efficacy and complication of humidified high flow nasal cannula versus nasal continuous positive airway pressure after treatment with surfactant in neonate with respiratory distress syndrome

Comparison of the efficacy and complication of humidified high flow nasal cannula versus nasal continuous positive airway pressure after treatment with surfactant in neonate with respiratory distress syndrome: a randomized clinical trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201709049014N181

Enrollment

Registered

2017-09-07

Start date

2017-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adult respiratory distress syndrome. Adult respiratory distress syndrome

Interventions

Intervention 1: Intervention group: Treatment with surfactant 200 mg/kg for one week plus continuous positive airway pressure through the nasal mask with a pressure of 4 cm water and FIO2 equal to 40%

Treatment - Other

Treatment - Drugs

Intervention group: Treatment with surfactant 200 mg/kg for one week plus continuous positive airway pressure through the nasal mask with a pressure of 4 cm water and FIO2 equal to 40% for one week.

Control group: Treatment with surfactant 200 mg/kg plus humidified high flow through bilateral nasal cannula with a pressure of 2 liter per minute for one week.

Eligibility

Sex/Gender

All

Age

7 Months to 9 Months

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age of 28 to 36 months; premature neonate; affecting with respiratory distress syndrome; hospitalization in NICU with 24 hours after birth. Exclusion criteria: Being born in other hospitals.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
The need for intubation. Timepoint: 72 hours after treatment. Method of measurement: with clinical examination.	—

Secondary

Measure	Time frame
Number days required for respiratory protection. Timepoint: 72 hours after treatment. Method of measurement: based on clinical examination.;Duration of admission. Timepoint: 72 hours after treatment. Method of measurement: according to medical records.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Masoomeh Mahdiankhoo

Sina Hospital

drmmahdiankhoo@gmail.com+98 81 3828 3939

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026