Protective effect of vitamin C on hepatotoxicity of tuberculosis drugs. Tuberculosis of lung
Conditions
Interventions
Intervention 1: First intervention group: Receiving 500 milligrams of vitamin C per day for two months. Intervention 2: Intervention group2:: Receiving one gram of vitamin C per day for two months. In
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Pulmonary and non pulmonary tuberculosis documented by sputum acid-fast smear, pathologic confirmation willingness to participate in the study
Exclusion criteria
Exclusion criteria: sign of acute or chronic liver disease according to history, physical examination and preliminary lab data
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disorders of the liver enzymes. Timepoint: Measure liver enzymes before the onset of intervention, one month after the start and two months after the start. Method of measurement: Examination of blood samples. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical symptoms and signs of hepatic toxicity. Timepoint: The beginning of the study. A month later. Two months later. Method of measurement: Liver test.;Sperm smear negative for TB. Timepoint: Second month. Method of measurement: Sample sputum examination for tuberculosis. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahnaz Amini
Mashhad University of Medical Sciences
Outcome results
None listed