Patients with decreased intracranial pressure. Cerebral edema due to birth injury
Conditions
Interventions
Intervention 1: Intervention group: Continuous infusion of 5% hypertonic saline, half a milliliter per kilogram per hour, along with furosemide, half a milligram per kilogram, over 24 hours for three
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Diagnosis of increased intracranial pressure based on clinical reports and tests Optic nerve diameter greater than 5.5 millimeter on initial ultrasound evaluation State of consciousness above 4 Age 18 to 70 years
Exclusion criteria
Exclusion criteria: Pregnancy Kidney failure or need for dialysis Coagulation disorders or serum sodium above 150 Milliequivalents per liter on admission Hypotension requiring vasopressors to maintain mean blood pressure above 60 Heart failure less than 40% Eye tear or injury Patients with pulmonary edema During the study, sodium levels above 160 Milliequivalents per liter
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intracranial pressure. Timepoint: Upon admission, 24, 48, and 72 hours after the start of treatment. Also 24 and 48 hours after the end of treatment. Method of measurement: Measurement using optic nerve diameter. | — |
Secondary
| Measure | Time frame |
|---|---|
| Level of consciousness. Timepoint: Every day during the intervention (for three days). Method of measurement: Glasgow coma scale.;Hemodynamic level. Timepoint: Every day during the intervention (for three days). Method of measurement: Your blood pressure, heart rate, and urine volume will be checked.;Serum sodium and potassium. Timepoint: Every six hours for three days. Method of measurement: Laboratory findings report. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactOmid Moradimoghadam
Iran University of Medical Sciences
Outcome results
None listed