The effect of protein with different doses on nitrogen balance

The effect of different doses of protein on nitrogen balance and clinical outcomes in intensive care unit patients

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170903036041N6

Enrollment

Registered

2023-07-06

Start date

2023-07-08

Completion date

Unknown

Last updated

2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients admitted to the intensive care unit. Encounter for other specified special examinations

Interventions

Intervention 1: The first intervention group: protein with a dose of 2.6 grams per kilogram of body weight daily for seven days, produced by Karen Pharmaceutical Company. Intervention 2: The second in

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age over 18 years At least 11 days of hospitalization in the intensive care unit

Exclusion criteria

Exclusion criteria: Death or discharge before 11 days of hospitalization in the intensive care unit Patients with liver, kidney and dialysis failure Anuric, oliguric or diarrhea patients Patients with high drain secretions A glomerular filtration rate less than 50

Design outcomes

Primary

Measure	Time frame
Nitrogen balance. Timepoint: Urine 24 hours admission time, time to reach the protein target and the 11 day study. Method of measurement: Based on the measurement of urea concentration in urine.;Thickness of biceps brachii muscle. Timepoint: Beginning and day 11 of the study. Method of measurement: Sonography.	—

Secondary

Measure	Time frame
Duration of use of mechanical ventilation. Timepoint: Duration of hospitalization. Method of measurement: Visit the patient/patients' files.;The duration of the patient's hospitalization in the intensive care unit. Timepoint: The total number of days the patient is in the ward. Method of measurement: Patients' files.;The number of positive cultures of nosocomial infection. Timepoint: The duration of the patient's hospitalization in the intensive care unit. Method of measurement: The number of positive culture results.;Mortality. Timepoint: 28 days after receiving interventions. Method of measurement: The discharge status of the patient as well as telephone follow-up 28 days after receiving the intervention.	—

Measure

Time frame

Duration of use of mechanical ventilation. Timepoint: Duration of hospitalization. Method of measurement: Visit the patient/patients' files.;The duration of the patient's hospitalization in the intensive care unit. Timepoint: The total number of days the patient is in the ward. Method of measurement: Patients' files.;The number of positive cultures of nosocomial infection. Timepoint: The duration of the patient's hospitalization in the intensive care unit. Method of measurement: The number of positive culture results.;Mortality. Timepoint: 28 days after receiving interventions. Method of measurement: The discharge status of the patient as well as telephone follow-up 28 days after receiving the intervention.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactRashin Taghizadeh

Iran University of Medical Sciences

taghizadehrashin@gmail.com+98 21 6653 9233

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026