The Effect of L-Carnitine supplementation administration rout on the prognosis of patients

The Effect of L-Carnitine supplementation administration rout on inflammatory, metabolic markers and the prognosis of patients admitted to the intensive care unit

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170903036041N4

Enrollment

135

Registered

2023-04-30

Start date

2023-04-21

Completion date

Unknown

Last updated

2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients admitted to the intensive care unit. Follow-up examination after unspecified treatment for other conditions

Interventions

Intervention 1: Intervention group: L-carnitine capsules will be prescribed 1 gram orally, 4 times a day for 3-7 days. Intervention 2: Intervention group: L-carnitine will be administered intravenousl

Eligibility

Sex/Gender

All

Age

17 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients admitted to the Intensive Care Unit At least 17 years old

Exclusion criteria

Exclusion criteria: History of taking L-carnitine supplements in the last month Taking corticosteroids and NSAIDs Severe cardiovascular diseases Pregnancy Breastfeeding

Design outcomes

Primary

Measure	Time frame
C-Reactive Protein. Timepoint: The beginning of the study, the third and seventh days after the intervention. Method of measurement: Blood test.;Erythrocyte Sedimentation Rate. Timepoint: The beginning of the study, the third and seventh days after the intervention. Method of measurement: Blood test.;Fasting Blood Sugar. Timepoint: The beginning of the study, the third and seventh days after the intervention. Method of measurement: Blood test.;Insulin. Timepoint: The beginning of the study, the third and seventh days after the intervention. Method of measurement: Blood test.	—

Measure

Time frame

C-Reactive Protein. Timepoint: The beginning of the study, the third and seventh days after the intervention. Method of measurement: Blood test.;Erythrocyte Sedimentation Rate. Timepoint: The beginning of the study, the third and seventh days after the intervention. Method of measurement: Blood test.;Fasting Blood Sugar. Timepoint: The beginning of the study, the third and seventh days after the intervention. Method of measurement: Blood test.;Insulin. Timepoint: The beginning of the study, the third and seventh days after the intervention. Method of measurement: Blood test.

—

Secondary

Measure	Time frame
Cholesterol. Timepoint: The beginning of the study, the third and seventh days after the intervention. Method of measurement: Blood test.;Triglyceride. Timepoint: The beginning of the study, the third and seventh days after the intervention. Method of measurement: Blood test.;Low-density lipoprotein. Timepoint: The beginning of the study, the third and seventh days after the intervention. Method of measurement: Blood test.;High-density lipoprotein. Timepoint: The beginning of the study, the third and seventh days after the intervention. Method of measurement: Blood test.;SOFA score. Timepoint: The beginning and end of the study. Method of measurement: SOFA checklist.;APACHE II score. Timepoint: The beginning and end of the study. Method of measurement: APACHE II score.;Nutrition score. Timepoint: The beginning and end of the study. Method of measurement: NUTRIC score.;Length of stay. Timepoint: Hospitalization days. Method of measurement: Count the number of days.	—

Measure

Time frame

Cholesterol. Timepoint: The beginning of the study, the third and seventh days after the intervention. Method of measurement: Blood test.;Triglyceride. Timepoint: The beginning of the study, the third and seventh days after the intervention. Method of measurement: Blood test.;Low-density lipoprotein. Timepoint: The beginning of the study, the third and seventh days after the intervention. Method of measurement: Blood test.;High-density lipoprotein. Timepoint: The beginning of the study, the third and seventh days after the intervention. Method of measurement: Blood test.;SOFA score. Timepoint: The beginning and end of the study. Method of measurement: SOFA checklist.;APACHE II score. Timepoint: The beginning and end of the study. Method of measurement: APACHE II score.;Nutrition score. Timepoint: The beginning and end of the study. Method of measurement: NUTRIC score.;Length of stay. Timepoint: Hospitalization days. Method of measurement: Count the number of days.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactArzhang Ebrahimi Fard

Iran University of Medical Sciences

emohaghegh96@yahoo.com+98 21 6653 9260

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026