Evaluation of Effectiveness of Different Dosage of Neostigmine in Combination with Metoclopramide, on Gastric Residual Volume

Evaluation of Effectiveness of Different Dosage of Neostigmine in Combination with Metoclopramide, on Gastric Residual Volume, in Enteral Nutrition, in Hospitalized Patients in Intensive Care Unit

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170903036041N1

Enrollment

165

Registered

2017-12-16

Start date

2017-06-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastric residual volume.

Interventions

Intervention 1: (Gold standard group): Metoclopramide will be prescribed five milligrams in every eight hours by IV.slow method during one minute. In addition, one milligram of Neostigminedose in dilu

Treatment - Drugs

(Gold standard group): Metoclopramide will be prescribed five milligrams in every eight hours by IV.slow method during one minute. In addition, one milligram of Neostigminedose in dilute solution of 1

(Intervention group 2): Metoclopramide will be prescribed five milligrams in every eight hours by IV.slow method during one minute. In addition, two milligrams of Neostigmine dose in dilute solution o

(Intervention group 1): Metoclopramide will be prescribed five milligrams in every eight hours by IV.slow method during one minute. In addition, one and a half milligrams of Neostigmine dose in dilute

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Enteral nutrition feeding After three hours from the last gavage gastric residual volume =50% Age 18-60

Exclusion criteria

Exclusion criteria: Diabetes mellitus disease Atrioventricular block Heart rate 2 milligram/deciliter Hypokalemia Concomitant medication with Cyclosporine Digoxin and Monoamine Oxidase inhibitors

Design outcomes

Primary

Measure	Time frame
Gastric residual volume. Timepoint: three hours after the completion of the infusion. Method of measurement: Cc.	—

Secondary

Measure	Time frame
Age. Timepoint: At the time of entering the study. Method of measurement: Chronological age.;Blood pressure. Timepoint: Recorded during the measurement of the gastric remaining volume. Method of measurement: mmHg (millimeters of mercury).;Respiratory rate. Timepoint: Recorded during the measurement of the gastric remaining volume. Method of measurement: The number of movements indicative of inspiration and expiration per unit time.;Heart rate. Timepoint: Recorded during the measurement of the Gastric remaining volume. Method of measurement: Number of contractions of the heart per minute (bpm).	—

Measure

Time frame

Age. Timepoint: At the time of entering the study. Method of measurement: Chronological age.;Blood pressure. Timepoint: Recorded during the measurement of the gastric remaining volume. Method of measurement: mmHg (millimeters of mercury).;Respiratory rate. Timepoint: Recorded during the measurement of the gastric remaining volume. Method of measurement: The number of movements indicative of inspiration and expiration per unit time.;Heart rate. Timepoint: Recorded during the measurement of the Gastric remaining volume. Method of measurement: Number of contractions of the heart per minute (bpm).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactOmid Moradi Moghadam

Iran University of Medical Science

moradimoghadam.o@iums.ac.ir+98 912 124 4560

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026