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Compare the effect of ondansetron and Dexamethasone with metoclopramide and Dexamethasone in the control of nausea and vomiting after chemotherapy

Compare the effect of ondansetron and Dexamethasone with metoclopramide and Dexamethasone in the control of nausea and vomiting after chemotherapy in cancer patients referred to Imam Hossein hospitals of Shahroud on 2017, a randomized double blind clinical trial

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
IRCT
Registry ID
IRCT20170902036032N1
Enrollment
86
Registered
2018-02-25
Start date
2017-12-22
Completion date
Unknown
Last updated
2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Under chemotherapy. Encounter for antineoplastic chemotherapy

Interventions

Intervention 1: Intervention group: Ondonestrone 0 / 1mg / kg with 2 cc normal saline plus 8 mg dexamethasone intravenously. Intervention 2: Control group: Metoclopramide 0.15 mg / kg plus 8 mg dexame

Sponsors

Shahroud University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 65 Years

Inclusion criteria

Inclusion criteria: A definitive diagnosis of a cancer that needs chemotherapy There is no other systemic disease (such as obstructive bowel disease and gastroenteritis, central nervous system problems, and equilibrium problems) Have a previous history of chemotherapy at least three times Age range 15 to 65 years Fear and complain about severe and fairly intense nausea and vomiting in previous chemotherapy No use oral antinausea or injection medicines in the last 7 days Desire and satisfaction to enter the study

Exclusion criteria

Exclusion criteria: Use an anti-nausea and vomiting medicine for at least the past 7 days Dissatisfaction with this treatment Those who use drugs There is a severe allergic reaction to either of the two drugs, Endonestrone and Metoclopramide Dissatisfaction with cooperation and participation in the project

Design outcomes

Primary

MeasureTime frame
Severity of pain. Timepoint: After treatment. Method of measurement: Visual Scale.;Nausea and vomiting. Timepoint: After treatment. Method of measurement: Visual Scale.;Complication after treatment of two drugs. Timepoint: After treatment. Method of measurement: Visual Scale.;Severe nausea after treatment. Timepoint: After treatment. Method of measurement: Visual Scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehrshad Mousapour

Shahroud University of Medical Sciences

mousapour@shmu.ac.ir+98 21 7792 6610

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026