A comparison between changes in cardio-vascular variables with the methode of continuous infusion of Dexmedetomidine and Remifentanil for controlled hypotensive anesthesia in lumbar discopathy surgery

A Comparision of hemodynamic changes between Dexmedetomidine infusion and Remifantanil infusion for controlled hypotensive anesthesia in lumbar discopathy surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017083136009N1

Enrollment

Registered

2017-11-07

Start date

2017-06-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lumbar discopathy. Other intervertebral disc disorders

Interventions

Intervention 1: Intervention group: continuous infusion of Dexmedetomidine , 0.7-0.3 µg per kg body weight per hour plus continuous infusion of propofol, 150-50 µg per kg body weight per minute. Inter

Treatment - Drugs

Intervention group: continuous infusion of Dexmedetomidine , 0.7-0.3 µg per kg body weight per hour plus continuous infusion of propofol, 150-50 µg per kg body weight per minute

Control group: Continuous infusion of Remifentanil, 1-0.1 micro-grams per kg body weight per hour plus continuous infusion of propofol, 150-50 micro-grams per kilogram body weight per minute

Eligibility

Sex/Gender

All

Age

20 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients with lumbar discopathy of physical state I and II. Exclusion criteria: any blood disorders and coagulative disorders; history of uncontrolled high blood pressure; taking anti-coagulative drugs; history of lumbar discopathy surgery; history of lumbar trauma

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Blood pressure. Timepoint: Before the surgery, during the surgery, after the surgery. Method of measurement: Invasive arterial blood pressure monitoring.;Bleeding. Timepoint: Before the surgery, during the surgery, after the surgery. Method of measurement: Calculation the amount of bleeding: the blood in the bottle of the suction machine in addition to the blood in the gases.;Urinary output. Timepoint: Before the surgery, during the surgery, after the surgery. Method of measurement: The volume of urine accumulated in the urine bag.	—

Measure

Time frame

Blood pressure. Timepoint: Before the surgery, during the surgery, after the surgery. Method of measurement: Invasive arterial blood pressure monitoring.;Bleeding. Timepoint: Before the surgery, during the surgery, after the surgery. Method of measurement: Calculation the amount of bleeding: the blood in the bottle of the suction machine in addition to the blood in the gases.;Urinary output. Timepoint: Before the surgery, during the surgery, after the surgery. Method of measurement: The volume of urine accumulated in the urine bag.

—

Secondary

Measure	Time frame
The interval between extubation and complete consciousness. Timepoint: After the surgery. Method of measurement: observation.;Duration of the surgery. Timepoint: After the surgery. Method of measurement: observation.;The time that there is a need to prescribe an analgesic. Timepoint: After the surgery. Method of measurement: observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahdis Vakili

Ahvaz Jundishapur University of Medical Sciences

mahdisvakili@ymail.com+98 916 830 0423

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026