Comparison the effect of intravenous Tranexamic Acid and sublingual Misoprostol and Oxytocin to reducing of post- cesarean hemorrhage

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201708308611N6

Enrollment

150

Registered

2017-09-20

Start date

2017-01-30

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postpartum haemorrhage. Postpartum haemorrhage

Interventions

Intervention 1: Intervention group: first group will receive 400 micrograms of sublingual Misoprostol after removing placenta+ receive 20 Units of Oxytocin after removing placenta immediatly. Interven

Treatment - Drugs

Intervention group: first group will receive 400 micrograms of sublingual Misoprostol after removing placenta+ receive 20 Units of Oxytocin after removing placenta immediatly

Intervention group: second group,will injected 1gr of intravenous Tranexamic Acid into 20 c.c of 5% Dextrosewaters slowly before begining cesarean+ receive 20 Units of Oxytocin after removing placent

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Inclusion criteria are singleton pregnant women with 37- 40 weeks gestational ages, first gravida and maximum second gravida; previous cesarean section with lower segment incision. Exclusion criteria: preeclampsia; abnormal placenta; previous uterine rupture.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Blood pressure. Timepoint: Every 5 minutes during the section and every 30 minutes up to an hour after cesarean. Method of measurement: Blood pressure monitor.;Pluse rate. Timepoint: Every 5 minutes during the section and every 30 minutes up to an hour after cesarean. Method of measurement: Blood pressure monitor.;Volume od bleeding. Timepoint: After removing placenta. Method of measurement: Through suction, weight of cesarean section's set and consumed gases.	—

Measure

Time frame

Blood pressure. Timepoint: Every 5 minutes during the section and every 30 minutes up to an hour after cesarean. Method of measurement: Blood pressure monitor.;Pluse rate. Timepoint: Every 5 minutes during the section and every 30 minutes up to an hour after cesarean. Method of measurement: Blood pressure monitor.;Volume od bleeding. Timepoint: After removing placenta. Method of measurement: Through suction, weight of cesarean section's set and consumed gases.

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Secondary

Measure	Time frame
Nausea. Timepoint: One hour after cesarean section. Method of measurement: Ask the patient.;Hemoglobin. Timepoint: At the time of entering the patient's in the ward and 24 hours after cesarean section. Method of measurement: Blood sample.;Fever. Timepoint: One hour after cesarean section. Method of measurement: Thermometer.;Shivering. Timepoint: One hour after cesarean section. Method of measurement: Observation.	—

Measure

Time frame

Nausea. Timepoint: One hour after cesarean section. Method of measurement: Ask the patient.;Hemoglobin. Timepoint: At the time of entering the patient's in the ward and 24 hours after cesarean section. Method of measurement: Blood sample.;Fever. Timepoint: One hour after cesarean section. Method of measurement: Thermometer.;Shivering. Timepoint: One hour after cesarean section. Method of measurement: Observation.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAzarmidokht Shojaei

Kowsar Hospital

dr.shojaei.mdgyn@gmail.com+98 28 3223 6374

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 23, 2026