Ectopic pregnancy.. Ectopic pregnancy, unspecified
Conditions
Interventions
Intervention 1: Intervention group: In the group receiving methotrexate, a single dose of methotrexate with a dose of 50 mg per square meter of the body will be calculated and injected intramuscularly
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Proven ectopic pregnancy(EP) Patient age 18-40 years Serum level (BHCG) beta Human Chorionic Gonadotropin less than 5000 Serum hemoglobin level above 10 Serum platelet level above 150,000
Exclusion criteria
Exclusion criteria: unstability of vital signs and occurrence of symptoms related to internal bleeding. The presence of surgical indications (viewing the fetal heart, abdominal EP(ectopic pregnancy), size above 3.5 cm, EP rupture and abdominal bleeding) Contraindications for use of letrozole or methotrexate (chronic kidney, liver and blood diseases, immunodeficiency, breastfeeding, active lung disease, peptic ulcer, simultaneous intrauterine pregnancy, drug interactions, severe drug sensitivity)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum levels of beta Human Chorionic Gonadotropin(BHCG). Timepoint: The first day of treatment and days 4, 7 and 14 after treatment. Method of measurement: BHCG test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum levels of liver enzymes. Timepoint: The first day of treatment and 7 days after that. Method of measurement: Blood test.;Serum levels of creatinine. Timepoint: The first day of treatment and 7 days after that. Method of measurement: Blood test.;Serum hemoglobin level. Timepoint: The first day of treatment and 7 days after that. Method of measurement: Blood test.;Counting the number of blood platelets. Timepoint: The first day of treatment and 7 days after that. Method of measurement: Blood test.;Anti-Müllerian hormone serum level. Timepoint: The first day of treatment and 3 months after that. Method of measurement: Blood test.;Drug side effects. Timepoint: while taking medication. Method of measurement: check list.;History of ectopic pregnancy. Timepoint: The beginning of treatment. Method of measurement: check list.;Number of pregnancies. Timepoint: The beginning of treatment. Method of measurement: check list. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Farhanaz Mardanian.
Esfahan University of Medical Sciences
Outcome results
None listed