Effect of minocycline on radicular low back pain

Effect of Minocycline on Lumbar Radicular Pain: A Randomised Clinical Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170828035960N3

Enrollment

Registered

2020-04-29

Start date

2020-07-22

Completion date

Unknown

Last updated

2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic radicular low back pain. Other chronic pain

Interventions

Intervention 1: Intervention group: non-steroidal anti-inflammatory drugs/paracetamol+ minocycline and non-steroidal anti-inflammatory drugs/paracetamol+ pregabaline. Intervention 2: Control group: no

Eligibility

Sex/Gender

All

Age

20 Years to 80 Years

Inclusion criteria

Inclusion criteria: Lumbosacral pain with radiation to below the knee, and irrespective to the aetiology (tumors and metastasis are excluded) Participants aged between 20-80 No precipitating or previous disease or condition, as MS or Guillain-Barre,..... Pain score more than 4 according to NRS schedule Pain course more than 3 months LBP with radiation to below the knee, leg pain more severe than LBP

Exclusion criteria

Exclusion criteria: Sensitivity to minocycline Any neurologic, rheumatologic, cognitive, orthopedics disorders or infectious diseases Use of rescue medicine

Design outcomes

Primary

Measure	Time frame
Chronic pain l. Timepoint: Numerical Rating Scale will be assessed at the beginning, at the end of the first week, and at the end of the seond week of treatment. Method of measurement: Numerical Rating scale includes numbers zero through 10. Patients will be explained that number zero means "no Pain" and number 10 is "the worst pain" may be experienced during life of someone. Patients choose a number subjectively.;Neuropathic" pain. Timepoint: This questionnaire will be completed at the beginning, end of the first and the second weeks after initiating the trial. Method of measurement: In this questionnaire, a number devoted to each question, then by summing them the final score will be obtained. Scores more than 4 will be considered "neuropathic pain" with 90% of acuity.;Quality of life. Timepoint: This questionnaire will be completed at the beginning and at the end of the study. Method of measurement: This questinnaire is a qualitative one, We devoted a score to each answer to change it to a quantitative one, so statistical analysis can be done on the data.	—

Measure

Time frame

Chronic pain l. Timepoint: Numerical Rating Scale will be assessed at the beginning, at the end of the first week, and at the end of the seond week of treatment. Method of measurement: Numerical Rating scale includes numbers zero through 10. Patients will be explained that number zero means "no Pain" and number 10 is "the worst pain" may be experienced during life of someone. Patients choose a number subjectively.;Neuropathic" pain. Timepoint: This questionnaire will be completed at the beginning, end of the first and the second weeks after initiating the trial. Method of measurement: In this questionnaire, a number devoted to each question, then by summing them the final score will be obtained. Scores more than 4 will be considered "neuropathic pain" with 90% of acuity.;Quality of life. Timepoint: This questionnaire will be completed at the beginning and at the end of the study. Method of measurement: This questinnaire is a qualitative one, We devoted a score to each answer to change it to a quantitative one, so statistical analysis can be done on the data.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSasan Gazerani

Saveh University of Medical Sciences

s_gazerani@hotmail.com+98 86 4234 3395

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026