The effect of FSH administration with HCG at the time of trigger on IVF cycles outcomes

Comparison between FSH administration with HCG and HCG alone at the time of trigger in IVF cycles outcomes

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017082724512N5

Enrollment

152

Registered

2017-09-22

Start date

2017-08-01

Completion date

Unknown

Last updated

2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female infertility. Female infertility,unspecified

Interventions

Intervention 1: Patients in the first intervention group received injection of 450 IU FSH with 5000 IU hCG once on the day of oocyte triggering. Intervention 2: Patients in the second intervention g

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Infertile women who candidate for IVF cycles underwent GnRH antagonist protocol Fresh embryo transfer cycles

Exclusion criteria

Exclusion criteria: Women with history of endocrine disorders serum estradiol>2500pg/ml in day of trigger Intrauterine abnormality (uterine polyp; uterine myoma) Severe male factor Cycle cancellation or changing to intrauterine insemination A cycle containing preimplantation genetic diagnosis (PGD) Women who did not undergo embryo transfer due to the freeze-all policy Donor or surrogate cycle

Design outcomes

Primary

Measure	Time frame
Chemical pregnancy. Timepoint: 14 days after transfer. Method of measurement: BHCG test.;Clinical pregnancy. Timepoint: 2 weeks after positive BHCG. Method of measurement: Transvaginal sonography.	—

Secondary

Measure	Time frame
Fertilization proportion. Timepoint: Post oocyte retrival. Method of measurement: The number of fertilized oocytes divided by the total number of oocytes.;Oocyte recovery rate. Timepoint: After oocyte retrieval. Method of measurement: The number of retrieved oocytes divided by the number of follicles >10 mm in size counted on the day of trigger.;Oocyte maturity rate. Timepoint: After oocyte retrieval. Method of measurement: the number of metaphase II (MII) oocytes divided by the number of oocytes retrieved.;Fertilization rate. Timepoint: After formation of 2PNs. Method of measurement: the number of 2PNs divided by the total number of MII oocytes.;Implantation rate. Timepoint: After detection of gestational sac in ultrasonography. Method of measurement: the number of intrauterine gestational sacs observed by transvaginal ultrasonography divided by the total number of transferred embryos.	—

Measure

Time frame

Fertilization proportion. Timepoint: Post oocyte retrival. Method of measurement: The number of fertilized oocytes divided by the total number of oocytes.;Oocyte recovery rate. Timepoint: After oocyte retrieval. Method of measurement: The number of retrieved oocytes divided by the number of follicles >10 mm in size counted on the day of trigger.;Oocyte maturity rate. Timepoint: After oocyte retrieval. Method of measurement: the number of metaphase II (MII) oocytes divided by the number of oocytes retrieved.;Fertilization rate. Timepoint: After formation of 2PNs. Method of measurement: the number of 2PNs divided by the total number of MII oocytes.;Implantation rate. Timepoint: After detection of gestational sac in ultrasonography. Method of measurement: the number of intrauterine gestational sacs observed by transvaginal ultrasonography divided by the total number of transferred embryos.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactPro. Abbas Aflatoonian

Yazd Reproductive Sciences Institute

abbas_aflatoonian@yahoo.com+98 35 3824 7085

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 21, 2026