Investigating the safety and effect of prophylactic doses of neostigmine in the prevention of postoperative ileus

Investigating the safety and effect of prophylactic doses of neostigmine in the prevention of postoperative ileus after radical cystectomy - a randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170826035911N2

Enrollment

Registered

2025-03-24

Start date

2025-03-30

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Muscle Invasive bladder cancer. Malignant neoplasm of bladder

Interventions

Intervention 1: Intervention group: One milligram of neostigmine is infused in 30 minutes. Intervention 2: Control group: Under the same conditions as the Intervention group, they undergo a placebo in

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All patients fit for Radical Cystectomy

Exclusion criteria

Exclusion criteria: Patients with the history of convulsion, epilepsy, cardiac arrhythmia and respiratory problems

Design outcomes

Primary

Measure	Time frame
Ileus recovery. Timepoint: Second day after operation. Method of measurement: History and physical exam.;Adverse effects. Timepoint: After administration and till 7 days. Method of measurement: History and physical exam.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarzad Allameh

Shahid Beheshti University of Medical Sciences

farzadallame@gmail.com+98 912 388 5545

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026