Viral intestinal infection, unspecified. Viral intestinal infection, unspecified
Conditions
Interventions
Intervention 1: The children were divided in two groups in a simple randomized method. The first group was given oral Ondansetron (manufactured by Iranian company, World Health Company) with dose 0.2
Treatment - Drugs
The children were divided in two groups in a simple randomized method. The first group was given oral Ondansetron (manufactured by Iranian company, World Health Company) with dose 0.2 mg/kg. Oral flui
The second group received intramuscular injection of Ondansetron (manufactured by Iranian company, Tehran Chemistry Company) with dose 0.2 mg/kg. Oral fluid therapy begins 30 minutes after receiving t
Sponsors
Vice Chancellor of Research, Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
1 Years to 10 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria: Children aged 1 to 10 years with acute gastroenteritis and mild to moderate dehydration; The vomiting has started in the last 24 hours; There is at least one episode of vomiting, within the last 6 hours; The disease is feverless or has a mild fever (below 38 ° C of axillary). The exclusion criteria: Children who have received any antiemetic drugs within the last 6 hours; The presence of any chronic disease or alarm sign or symptoms such as headache or abdominal distention; There is severe dehydration or shock; Diarrhea is intense and has a frequency of more than once per hour; The patient has a history of any hypersensitivity to 5-HT3 receptor antagonists.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vomiting. Timepoint: 30 minutes after receiving ondancetron, then 4 hours later in the emergency department, then 48 hours after the administration of drug in home. Method of measurement: Direct view and parent question.;Require hospitalization. Timepoint: 30 minutes after receiving ondancetron, then 4 hours later in the emergency department, then 48 hours after the administration of drug in home. Method of measurement: Direct view and parent question. | — |
Secondary
| Measure | Time frame |
|---|---|
| Headache. Timepoint: 4 hours after receiving ondancetron in the emergency department. Method of measurement: In children older than 4 years of age, through questions from the children and their parents. In children younger than 4 years, there is an increase in restlessness and irritability through direct observation and asking from their parents.;Tachycardia. Timepoint: 4 hours after receiving ondancetron in the emergency department. Method of measurement: Using auscultation by therapist with stethoscope. In children 1-3 years, the palse rate more than 150 beats per minute, in 4 - 5 years old more than 135, in 6 - 8 years old more than 130 and in 8 - 10 years old more than 110 are abnormal and and considered to be tachycardia. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactKambiz Eftekhari
Bahrami Children's Hospital
Outcome results
None listed