Osteoarthritis. Arthrosis, unspecified
Conditions
Interventions
Intervention 1: Fifty patients apply topical bitter almond oil to the knee every 8 hours for 10 minutes during 1 month. Intervention 2: Fifty patients apply topical diclofenac to the knee every 8 hour
Treatment - Drugs
Treatment - Other
Placebo
Fifty patients apply topical bitter almond oil to the knee every 8 hours for 10 minutes during 1 month
Fifty patients apply topical diclofenac to the knee every 8 hours for 10 minutes during 1 month
Fifty patients massage the knee without application of any topical agent every 8 hours for 10 minutes during 1 month
Fifty patients apply topical placebo to the knee every 8 hours for 10 minutes during 1 month
Sponsors
Mashhad University of Medical Sciences
Iranian academic center for education culture and research
Eligibility
Sex/Gender
All
Age
40 Years to 85 Years
Inclusion criteria
Inclusion criteria: Male or female patients with 1 or 2 knees osteoarthritis according to the American College of Rheumatology criteria after physical examination and knee joint radiography Age of 40 to 85 years Flare of the disease after oral non-steroidal anti-inflammatory drug or acetaminophen discontinuation which have been used at least 3 days a week during the past month (flare means increase of at least 2 scores in the total pain subscale score in the beginning of the study.) Western Ontario and McMaster Universities (WOMAC) pain subscale index at least 9 out of 20 in the beginning of the study
Exclusion criteria
Exclusion criteria: Secondary osteoarthritis (due to a definite disease) Arthroscopy Knee surgery History of knee replacement surgery Infection Cardiovascular disease Hepatic disease Renal disease Other chronic inflammatory disease History of alcohol abuse History of drug abuse History of narcotic abuse Skin disease in the knee area Fibromyalgia Debilitating disease affecting the knee Pregnant women Women planning pregnancy Lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Extent of arthritis. Timepoint: Before intervention and 1 month after intervention. Method of measurement: The Western Ontario and McMaster Universities Arthritis Index questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Extent of joint stiffness. Timepoint: Before intervention and 1 month after intervention. Method of measurement: The Western Ontario and McMaster Universities Arthritis Index questionnaire.;Extent of joint pain. Timepoint: Before intervention and 1 month after intervention. Method of measurement: The Western Ontario and McMaster Universities Arthritis Index questionnaire.;Extent of physical function. Timepoint: Before intervention and 1 month after intervention. Method of measurement: The Western Ontario and McMaster Universities Arthritis Index questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Saeed Kianbakht
ACECR Institute of Medicinal Plants
Outcome results
None listed