knee osteoarthritis. Gonarthrosis
Conditions
Interventions
Intervention 1: linseed oil,three times a day on,topically on painful knee. Intervention 2: Diclofenac gel 1%,three times a day,topically on painful knee.
Treatment - Drugs
Placebo
linseed oil,three times a day on,topically on painful knee
Diclofenac gel 1%,three times a day,topically on painful knee
Sponsors
Vice chancellor for research,Fasa University of Medical Sciences
Eligibility
Sex/Gender
All
Age
35 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: the age between 35-70 years;at least having pain in one knee for past 3 months;recognition of osteoarthritis by the doctor according to American college of rheumatology classification criteria; recognition of grade I to III osteoarthritis by the doctor according to Kellegren-Lawrence(K-L)grading scale;absence of any congenital abnormality in lower extremity;written informed consent for inclusion. Exclusion Criteria: sensitivity and allergy to linseed or diclofenac gel or acetaminophen;skin disease in knee;patients with secondary osteoarthritis due to other bone joint disorders like rheumatoid arthritis, gout, infected arthritis, metabolic arthritis, traumatic arthritis; joint replacement; oral and topical use of corticostreoid in past 14 days;knee corticosteroid or hyaluronic acid injection in the past 90 days; other articular corticosteroid or hyaluronic acid injection in the past 1 month;topical or oral usage of painkillers in past 3 days;concomitant use of glucosamin or chondroitin sulfate;pregnancy and lactation; alcohol or drug addiction; disability to cooperate in filling the forms (cognitive or language disorder); patients with active peptic ulcer diseases and inflammatory bowl disease(IBD);BMI = 35 kg/m^2;physical modality in knee joint in past 2 weeks like physical therapy,acupuncture and Transcutaneous Electrical Nerve Stimulator (TENS).
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analogue scale. Timepoint: At the beginning of intervention,after2 weeks then after 4 weeks from the beginning of intervention. Method of measurement: Asking the patients. | — |
Secondary
| Measure | Time frame |
|---|---|
| Function in daily living (ADL). Timepoint: At the beginning of intervention,after 2 weeks then 4 weeks afterthe beginning of intervention. Method of measurement: KOOS questionnaire.;Other Symptoms. Timepoint: At the beginning of intervention,after 2 weeks then 4 weeks afterthe beginning of intervention. Method of measurement: KOOS questionnaire.;Pain. Timepoint: At the beginning of intervention,after 2 weeks then 4 weeks afterthe beginning of intervention. Method of measurement: KOOS questionnaire.;Function in sport and recreation(Sport/Rec). Timepoint: At the beginning of intervention,after 2 weeks then 4 weeks afterthe beginning of intervention. Method of measurement: KOOS questionnaire.;Knee related quality of life(QOL). Timepoint: At the beginning of intervention,after 2 weeks then 4 weeks afterthe beginning of intervention. Method of measurement: KOOS questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr.Alireza Askari
Fasa Universityof Medical Sciences
Outcome results
None listed