Knee osteoarthritis. Gonarthrosis
Conditions
Interventions
Intervention 1: Diclofenac 1% topical gel, three times a day on the l knee. Intervention 2: basil oil, three times a day, topically on knee.
Treatment - Drugs
basil oil, three times a day, topically on knee
Sponsors
Vice chancellor for research, Fasa University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: the age between 30-70 years old; patient's written informed consent for inclusion; diagnosis of osteoarthritis by the orthopedist according to American College of Rheumatology classification criteria; grade I to III osteoarthritis according to Kellegren-Lawrence system of classification; pain of at least one knee during 3 months ago; no congenital abnormality of lower extremity. Exclusion Criteria: hypersensitivity to basil oil or Diclofenac gel or celecoxib; unwillingness to continue to participate in the study; secondary osteoarthritis due to rheumatologic diseases like rheumatoid arthritis, gout, pseudo gout, infected arthritis, metabolic arthritis, traumatic arthritis; joint replacement; concomitant use of glucosamine and chondroitin sulfate; knee injection of corticosteroid or hyaluronic acid in the past 3 months; other articular corticosteroid or hyaluronic acid injection in the past 1 month; use of oral or topical analgesic drugs 3 days before enrollment; pregnancy or Lactating women; alcohol addiction; drug abuse; using oral or topical corticosteroid 14 days days before enrollment; skin lesions of knee; disability to cooperate in filling the forms (cognitive or language disorder); the patient who use drugs that interact with celexib (e.g. lithium, fluconazole, warfarin, diuretics, ACE inhibitors like captopril, ARBs like losartan); patient with IBD or PUD; obesity (BMI = 35 kg/m^2); use of physical modalities 2 weeks before enrollment (such as physical treatment, Acupuncture and Transcutaneous Electrical Nerve Stimulator).
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| General status of pain, physical function and stiffness of patients. Timepoint: At the beginning of intervention and after 2 week, 4 weeks after the beginning of intervention. Method of measurement: WOMAC questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Knee flexion angle. Timepoint: At the beginning of intervention and 2 week, 4 weeks after the beginning of intervention. Method of measurement: by using of standard goniometer.;Speed of walking. Timepoint: At the beginning of intervention and 2 week, 4 weeks after the beginning of intervention. Method of measurement: with measuring time of 8 meters walking.;The need for celexib 100 milligrams tablets. Timepoint: At the beginning of intervention and 2 week, 4 weeks after the beginning of intervention. Method of measurement: Asking from patients.;Joint stiffness. Timepoint: At the beginning of intervention and 2 week, 4 weeks after the beginning of intervention. Method of measurement: WOMAC questionnaire.;Phyisical activity. Timepoint: At the beginning of intervention and 2 week, 4 weeks after the beginning of intervention. Method of measurement: Asking from patients.;Knee pain. Timepoint: At the beginning of intervention and 2 week, 4 weeks after the beginning of intervention. Method of measurement: VAS ruler, WOMAC questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSayyed Ali Ravansalar
Fasa University of Medical Sciences
Outcome results
None listed