metabolic syndrome. Obesity due to excess calories, Non-insulin-dependent diabetes mellitus with unspecified complications,Secondary hypertension, unspecified
Conditions
Interventions
Intervention 1: Intervention group: patients will receive a daily two capsules containing 400 mg of green coffee extract, for two months. Capsules should taken 30 minutes before breakfast and lunch w
Treatment - Drugs
Placebo
Intervention group: patients will receive a daily two capsules containing 400 mg of green coffee extract, for two months. Capsules should taken 30 minutes before breakfast and lunch with glass of wat
control group: patients will receive a daily two placebo capsules , for two months. Capsules should taken 30 minutes before breakfast and lunch with a glass of water.
Sponsors
Vice chancellor for research, Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
25 Years to 55 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: people with metabolic syndrome; 25-50 year old person; willingness to cooperate. Exclusion criteria: use of lipid or glucose or blood pressure lowering agents; use of body weight loss medications; Addiction and Smoking; Menopause; Sensitivity to placebo; cancer; cardiovascular disease; liver disorders; kidney disease and anemia; use of antioxidant supplements, fish oil supplements and alcohol; pregnancy and lactation
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum Chemerin. Timepoint: At baseline and after 2 month of intervention. Method of measurement: ELISA.;Malondialdehyde. Timepoint: At baseline and after 2 month of intervention. Method of measurement: Spectrophotometry of Thiobarbituric Acid. | — |
Secondary
| Measure | Time frame |
|---|---|
| Whight. Timepoint: At baseine and 4th and 8th weeks. Method of measurement: scale.;BMI. Timepoint: At baseine and 4th and 8th weeks. Method of measurement: W/H.t2.;Waist circumference. Timepoint: At baseine and 4th and 8th weeks. Method of measurement: Standard plastic tape.;Hip circumference. Timepoint: At baseine and 4th and 8th weeks. Method of measurement: Standard plastic tape.;Waist/Hip ratio. Timepoint: At baseine and 4th and 8th weeks. Method of measurement: Waist / Hip.;Blood pressure. Timepoint: At baseine and 4th and 8th weeks. Method of measurement: Standard mercury manometer.;Physical activity. Timepoint: At baseine and 4th and 8th weeks. Method of measurement: The International physical activity questionnaire.;Triglyceride. Timepoint: Beginning of the study and after two months. Method of measurement: Enzymatic and colorimetric method.;Total Cholesterol. Timepoint: Beginning of the study and after two months. Method of measurement: Enzymatic and colorimetric method.;LDL-C. Timepoint: Beginning of the study and after two months. Method of measurement: Enzymatic and colorimetric method.;HDL-C. Timepoint: Beginning of the study and after two months. Method of measurement: Enzymatic and colorimetric method.;Fasting blood glucose. Timepoint: Beginning of the study and after two months. Method of measurement: Glucose oxidase enzymatic and colorimetric.;Insulin level. Timepoint: Beginning of the study and after two months. Method of measurement: Enzymatically using autoanalyzer.;Insulin resistance. Timepoint: Beginning of the study and after two months. Method of measurement: HOMAIR.;HbA1c. Timepoint: Beginning of the study and after two months. Method of measurement: Colorimetric - Ion Spectrophotometer.;Nutritional status. Timepoint: At baseine and 4th and 8th weeks. Method of measurement: The questionnaires and Software nutrition 4. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehdi Fasihi
Tabriz University of Medical Sciences
Outcome results
None listed