Effects of Memantine on tension-type headache

To survey the effects of Memantine in comparison routine treatment for improving tension-type headache

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017081635710N2

Enrollment

Registered

2017-09-17

Start date

2017-09-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

tension-type headache. Chronic tension-type headache

Interventions

Intervention 1: Intervention group: Memantine (5-15mg) every day for 3 months. Intervention 2: Control group: Amitriptyline (20mg) every day for 3 months.

Treatment - Drugs

Intervention group: Memantine (5-15mg) every day for 3 months

Control group: Amitriptyline (20mg) every day for 3 months

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Patients with confirmed tension-type headache; Aged between 18 and 65 years. Exclusion criteria: Patients with the history of smoking, or alcohol; Pregnancy or breastfeeding; Use of antipsychotics or antidepressants in the past 3 months

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Migraine disability assessment scale. Timepoint: Before intervention - 3 months after intervention. Method of measurement: MIDAS questionnaire.	—

Secondary

Measure	Time frame
Headache severity. Timepoint: Before intervention - 3 months after intervention. Method of measurement: Visual analogue scale.;Number of headache days per month. Timepoint: Before intervention - 3 months after intervention. Method of measurement: patients' self-report.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactEhsan Jelodari

Shiraz University of Medical Sciences

ehsan2313@yahoo.com+98 71 3612 1000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026