Effect of weight loss on improvement of liver inflammation and fibrosis in non- alcoholic fatty liver patients through calorie restricted diet

Studying the effect of weight loss through calorie restricted diet on apoptotic factor levels of cytokeratin 18 and indicators of liver dysfunction in patients with non-alcoholic steatohepatitis (NASH)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017081535707N1

Enrollment

Registered

2017-10-15

Start date

2017-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-Alcoholic Fatty Liver - Non -Alcoholic Steatohepatitis. Other specified inflammatory liver diseases

Interventions

This study includes a group of 60 patients with non-alcoholic fatty liver disease. Intervention is performed for all of these patients and the study does not have the control group. The intervention i

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1. BMI 25-40? Hepatic fibrosis 2 and higher? Liver enzymes 1.5 times more natural Exclusion criteria: Viral hepatitis B, c ? Liver Cancer? alcohol consumption? Pregnancy ? Hepatic autoimmune diseases? Taking hepatotoxic drugs? Taking vitamin D supplement pills ? Patient's denial? Failure to observe the diet

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Cytokeratin 18. Timepoint: First, 3 and 6 months after intervention. Method of measurement: ELIZA Kit.;Liver dysfunction factors. Timepoint: First.3 and 6 months after intervention. Method of measurement: Biochemistry Lab.	—

Secondary

Measure	Time frame
Liver Fibrosis. Timepoint: First,6 months after intervention. Method of measurement: Fibroscan Of liver.;Anthropometric measurements. Timepoint: first, 3 and 6 months after the intervention. Method of measurement: BIA device. Measuring body size with meter.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Mohammad Safarian

Mashhad University of Medical Sciences

med.faculty[AT]mums.ac.irsafarianm@mums.ac.irmohammadps941@mums.ac.ir+51 38828888051

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026