Comparison of the efficacy of different doses of buprenorphine (8mg, 2mg) on the reduction of methamphetamine(crystal, Shishe) withdrawal symptoms, depression, suicidal thought and anxiety

Comparison of the efficacy of different doses of buprenorphine (8mg, 2mg) on the reduction of methamphetamine withdrawal symptoms, depression, suicidal thought and anxiety.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017081525160N8

Enrollment

Registered

2017-08-25

Start date

2017-08-15

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Methamphetamine Dependency. Mental and behavioural disorders due to use of other stimulants, including caffeine

Interventions

Intervention 1: We will use buprenorphine 8mg sublingual daily for one group for at least 5 days. Intervention 2: We will use buprenorphine 2 mg sublingual daily for the other group at least 5 days. I

Treatment - Drugs

Placebo

We will use buprenorphine 8mg sublingual daily for one group for at least 5 days

We will use buprenorphine 2 mg sublingual daily for the other group at least 5 days.

We will use placebo sublingual daily for one group for at least 5 days

Eligibility

Sex/Gender

Male

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age: 18-60 ;informed consent; methamphetamine dependence Exclusion criteria:Patients unwilling to participate at beginning or during the study; use of another substance except Methamphetamine as of the main substance.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Craving, depression, suicidal thoughts and anxiety. Timepoint: Daily for 5 days. Method of measurement: Questionnaire and interview.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactJamshid Ahmadi M.D.

Shiraz University of Medical Sciences

jamshid_ahmadi@yahoo.com+98 71 3646 1511

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026