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Effects of venlafaxine and amitriptyline on migraines

The Comparative Study of Preventive Effects of Venlafaxine with Amitriptyline in Migrainous Patients

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20170814035697N6
Enrollment
80
Registered
2020-12-25
Start date
2020-07-05
Completion date
Unknown
Last updated
2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Migraine. Migraine

Interventions

Intervention 1: Intervention group: venlafaxine taking group. Intervention in this group: Patients will take one venlafaxine tablet with a dose of 37.5 per day made by Sami Saz Pharmaceutical Company

Sponsors

Oroumia University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: People with migraine People who experience 3 or more attacks each month People who have never used amitriptyline or venlafaxine to manage their attacks

Exclusion criteria

Exclusion criteria: People who are pregnant or planning to become pregnant in the next two months People with a history of specific cardiovascular or cerebral surgery People with a history of seizures People with high blood pressure people with Benign prostatic hyperplasia People with glaucoma

Design outcomes

Primary

MeasureTime frame
Incidence of Headache. Timepoint: At the beginning of the study and two months after the start of the study. Method of measurement: The six-item Headache Impact Test. Headache Impact Test is a tool used to measure the impact headaches have on your ability to function on the job, at school, at home and in social situations.Your score shows you the effect that headaches have on normal daily life and your ability to function. Headache Impact Test was developed by an international team of headache experts from neurology and primary care medicine in collaboration with the psycho metricians who developed the SF-36®health assessment tool. This questionnaire was designed to help you describe and communicate the way you feel and what you can not do because of headaches.

Secondary

MeasureTime frame
Severity of attacks. Timepoint: At the beginning of the study and two months after the start of the study. Method of measurement: The six-item Headache Impact Test.;Duration of attacks. Timepoint: At the beginning of the study and two months after the start of the study. Method of measurement: The six-item Headache Impact Test.;Number of attacks. Timepoint: At the beginning of the study and two months after the start of the study. Method of measurement: The six-item Headache Impact Test.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohaddeseh Hedayat

Oroumia University of Medical Sciences

Mohaddeseh_Hedayat@yahoo.com+98 44 3275 4993

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026