Skip to content

A Randomized Placebo-Controlled Trial of gabapentin versus midazolam for Prevention of Post Operative Nausea and Vomiting after general anesthesia

A Randomized Placebo-Controlled Trial of gabapentin versus midazolam for Prevention of Post Operative Nausea and Vomiting after general anesthesia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20170814035689N3
Enrollment
96
Registered
2018-04-22
Start date
2018-02-04
Completion date
Unknown
Last updated
2018-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

post operative Nausea and vomiting. Nausea with vomiting, unspecified

Interventions

Intervention 1: Intervention group 1: gabapentin (razak company) 300mg po, 1hour before surgery. Intervention 2: Intervention group 2: midazolam (caspian) 0.025 mg/kg befor induction. Intervention 3:

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 65 Years

Inclusion criteria

Inclusion criteria: The study population of patients referring to Imam Khomeini Hospital and the sample would include patients who are required to perform Mastectomy is referred to Vali Asr operation room. After providing the necessary explanations, patients will be informed of the consent of the study.In this study, patients aged 20 to 65 years who were admitted for mastectomy elective with ASA class 1 and 2, were selected and divided into three groups.

Exclusion criteria

Exclusion criteria: Exit from the study included pre-operative history of use of analgesics and drugs, history of corticosteroid use, history of chronic pulmonary disease, history of postoperative nausea and vomiting, diabetes, motion sickness, history of drug use and antiemetic drugs. And patients with a BMI of 30 kg / m 2

Design outcomes

Primary

MeasureTime frame
The number of vomiting after surgery. Timepoint: Up to 24 hours after surgery. Method of measurement: checklist.

Secondary

MeasureTime frame
Pain severity. Timepoint: since one day after surgery. Method of measurement: question.;Serum intake. Timepoint: while surgery. Method of measurement: quentitive.

Countries

Iran (Islamic Republic of)

Contacts

Public Contactmohammad mojtaba rohani

Tehran University of Medical Sciences

rohani.mmojtaba@gmail.com+98 21 81631

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026