Bone loss. Gingivitis and periodontal diseases
Conditions
Interventions
Intervention 1: Risedronate 2% gel
once, during surgery
localized in bone defect. Intervention 2: Placebo gel
localized in bone defect.
Treatment - Drugs
Placebo
Risedronate 2% gel
Placebo gel
Sponsors
Vice chancellor for research Islamic Azad University, Dental Tehran Branch
Eligibility
Sex/Gender
Male
Age
6 Months to 7 Months
Inclusion criteria
Inclusion criteria: Inclusion criteria: Animals with same weight, age and gender; without disease. Exclusion criteria: Diagnosis of the disease.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The amount of bone filling. Timepoint: Four weeks after intervention, eight weeks after intervention. Method of measurement: by microscopic observation.;Inflammation. Timepoint: Four weeks after intervention, eight weeks after intervention. Method of measurement: by microscopic observation.;Osteoblasts. Timepoint: Four weeks after intervention, eight weeks after intervention. Method of measurement: by microscopic observation.;Osteoclasts. Timepoint: Four weeks after intervention, eight weeks after intervention. Method of measurement: by microscopic observation.;Foreign body reaction. Timepoint: Four weeks after intervention, eight weeks after intervention. Method of measurement: by microscopic observation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Infection. Timepoint: Before intervention, during intervention, after intervention. Method of measurement: Observation, examination.;The presence of the disease. Timepoint: Before intervention, during intervention. Method of measurement: By the veterinarian. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Shirin Marzoughi
Islamic Azad University, Dental Tehran Branch
Outcome results
None listed