Nutritional Deficiencies. Endocrine, nutritional and metabolic diseases
Conditions
Interventions
Intervention 1: Intervention group: daily consumption of 100 g fortified bread by 500 IU of vitamin D for 3 month. Intervention 2: Intervention group: daily consumption of 100 g fortified bread by 100
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: 20-60 year-aged vitamin D deficiency Not intake of supplements containing vitamin D or fish oil during the last three months Not having clinical signs of diseases that interfere with vitamin D metabolism (liver and kidney disease) Not receiving drugs interfering with the metabolism of vitamin D (corticosteroids, estrogen)
Exclusion criteria
Exclusion criteria: any disease or need to use of medication which interferes with vitamin D metabolism pregnancy or breastfeeding any weight loss treatments
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum 25-hydroxyvitamin D concentration. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (3 months later). Method of measurement: ElISA.;Serum sugar and lipid profile. Timepoint: At the beginning of the study (before the intervention) and at the end of the study (3 months later). Method of measurement: Measurement of serum glucose and lipids will be done using an enzymatic method based on colorimetry using commercial kits (Pars Test, Iran) with automatic device (Selecta E, Vitalab, Netherland). | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure. Timepoint: At the beginning of the study (before the start of the intervention) and at the end of the study (3 months later). Method of measurement: Blood pressure will be measured by a digital barometer (BC 08, Beurer, Germany) after at least 15-10 minutes of rest and sitting. Blood pressure will be measured twice for each person and the average blood pressure for each person will be reported.;Serum concentrations of albumin, calcium, phosphorus and magnesium. Timepoint: At the beginning of the study (before the start of the intervention) and at the end of the study (3 months later). Method of measurement: Serum concentrations of albumin, calcium, phosphorus and magnesium will be performed based on colorimetric method, using commercial kits (Pars Test, Iran) by the automatic device (Selecta E, Vitalab, Netherland).;Urinary concentration of sodium, potassium, calcium, phosphorus, magnesium, creatinine and micro-albumin. Timepoint: At the beginning of the study (before the start of the intervention) and at the end of the study (3 months later). Method of measurement: Calcium, phosphorus, magnesium and creatinine (Pars Test, Iran) were measured by colorimetric method and microalbumin by Immunoturbidometric method using the commercial kit (Pars Test, Iran). and automatic device (Selecta E, Vitalab, Netherland).;Serum iPTH. Timepoint: At the beginning of the study (before the start of the intervention) and at the end of the study (3 months later). Method of measurement: The serum iPTH will be measured using commercial kits (DRG) in Germany and by immune-enzymatic (ELISA) method.;Anthropometry. Timepoint: At the beginning of the study (before the start of the intervention) and at the end of the study (3 months later). Method of measurement: The height will be measured without shoes by a stadiometer (Seca, Germany) with a sensitivity of 0.1 cm and weight with a digital scale (808 Seca, Germany) while wearing light clothes (with no coat or raincoat) with a | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHadith Tangestani
Tehran University of Medical Sciences
Outcome results
None listed