The effect of black cumin oil on Knee joints pain

Comparison of the effect of topical application of black cumin oil and diclofenac sodium topical gel on elderly knee pain

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017080835563N1

Enrollment

Registered

2017-10-27

Start date

2017-08-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee joint pain. Pain in joint

Interventions

Intervention 1: Control group: topical application of diclofenac sodium gel 1% (2 g in the morning and at night for 21 days, produced by Tehran Razak Company. Intervention 2: Intervention group: Local

Treatment - Drugs

Control group: topical application of diclofenac sodium gel 1% (2 g in the morning and at night for 21 days, produced by Tehran Razak Company.

Intervention group: Local application of black cumin oil (1 cc in the morning and night) for 21 days from the Isfahan Ganjineh osare Tabiat pharmaceutical company.

Eligibility

Sex/Gender

All

Age

60 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: being at the age of 60 to 80 years old; diagnosis of knee Osteoarthritis according to American College Rheumatologic Diagnostic Criteria; Crepitus; morning knee stiffness less than 30 minutes; ; Knee osteoarthritis was confirmed by a physician and radiographic evidence; inflammation in the knee examination. Exclusion criteria: blindness and Deafness and lack of communication; cancer; Addiction; treatment with corticosteroids and glucosamine.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Knee joint pain. Timepoint: Before the study - 10 days after the study - 21st day and the end of the study. Method of measurement: knee injery and osteoarthritis outcom score(koos).;Intensity of pain. Timepoint: Before the study - 10 days after the study - 21st day and the end of the study. Method of measurement: knee injery and osteoarthritis outcom score(koos).;Pain quality. Timepoint: Before the study - 10 days after the study - 21st day and the end of the study. Method of measurement: knee injery and osteoarthritis outcom score(koos).;Pain time. Timepoint: Before the study - 10 days after the study - 21st day and the end of the study. Method of measurement: knee injery and osteoarthritis outcom score(koos).;Joint stiffness. Timepoint: Before the study - 10 days after the study - 21st day and the end of the study. Method of measurement: knee injery and osteoarthritis outcom score(koos).;Daily activities. Timepoint: Before the study - 10 days after the study - 21st day and the end of the study. Method of measurement: knee injery and osteoarthritis outcom score(koos).;Recreational activities. Timepoint: Before the study - 10 days after the study - 21st day and the end of the study. Method of measurement: knee injery and osteoarthritis outcom score(koos).;Quality of Life. Timepoint: Before the study - 10 days after the study - 21st day and the end of the study. Method of measurement: knee injery and osteoarthritis outcom score(koos).	—

Measure

Time frame

Knee joint pain. Timepoint: Before the study - 10 days after the study - 21st day and the end of the study. Method of measurement: knee injery and osteoarthritis outcom score(koos).;Intensity of pain. Timepoint: Before the study - 10 days after the study - 21st day and the end of the study. Method of measurement: knee injery and osteoarthritis outcom score(koos).;Pain quality. Timepoint: Before the study - 10 days after the study - 21st day and the end of the study. Method of measurement: knee injery and osteoarthritis outcom score(koos).;Pain time. Timepoint: Before the study - 10 days after the study - 21st day and the end of the study. Method of measurement: knee injery and osteoarthritis outcom score(koos).;Joint stiffness. Timepoint: Before the study - 10 days after the study - 21st day and the end of the study. Method of measurement: knee injery and osteoarthritis outcom score(koos).;Daily activities. Timepoint: Before the study - 10 days after the study - 21st day and the end of the study. Method of measurement: knee injery and osteoarthritis outcom score(koos).;Recreational activities. Timepoint: Before the study - 10 days after the study - 21st day and the end of the study. Method of measurement: knee injery and osteoarthritis outcom score(koos).;Quality of Life. Timepoint: Before the study - 10 days after the study - 21st day and the end of the study. Method of measurement: knee injery and osteoarthritis outcom score(koos).

—

Secondary

Measure	Time frame
Advers drug reaction. Timepoint: Every week after the beginning of the study, one week after the end of the study. Method of measurement: Patient's report.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Azizi

Sabzevar University of Medical Sciences

azizi.azar@gmail.com+98 51 4464 0846

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026