acne vulgaris. Acne vulgaris
Conditions
Interventions
Intervention 1: Intervention group: Clindamycin phosphate niosomal solution1% twice daily. Intervention 2: Control group: 1% Clindamycin phosphate solution twice daily.
Treatment - Drugs
Intervention group: Clindamycin phosphate niosomal solution1% twice daily
Control group: 1% Clindamycin phosphate solution twice daily
Sponsors
Vice Chancellor for research of Kerman University of Medical Sciences
Eligibility
Sex/Gender
All
Age
12 Years to 30 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Mild to moderate acne vulgaris; Both male and female;age (12-30years); lack of treatment during the one month period before the study exclusion criteria: pregnancy; breast feeding; hypersensitivity to clindamycin; history of inflamatory bowel disease(IBD); history of neuromuscular junction blocker using; history of systemic retinoid using in the past 6 month; history of oral estrogen using in the past 3 month; history of topical retinoid and oral antibiotic using in the past 1 month; history of antimicrobial soap and comedogenic products using in the past 2 weeks; history of astringents and abrasive products using in the past 1 week; hirsutism; androgenetic alopecia; Polycystic ovarian syndrome.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acne severity. Timepoint: Baseline, two weeks after intervention ,four weeks after intervention, eight weeks after intervention, twelve weeks after intervention. Method of measurement: Inflammatory and non-inflammatory lesions count, mild acne: most non-inflammatory lesions or less than 15 inflammatory lesions, moderate acne: 15 to 50 inflamatory lesions.;Acne grading. Timepoint: Baseline, two weeks after intervention ,four weeks after intervention, eight weeks after intervention, twelve weeks after intervention. Method of measurement: Global Acne Grading system: The face is divided into five parts, forehead(2 factor), right and left cheek(2 factor), nose(1 factor), chin(1 factor), no lesions = 0, comedones = 1, papules = 2, pustules = 3 and nodules = 4. The score for each area (Local score) is calculated using the formula: Local score = Factor × Grade (0-4). The global score is the sum of local scores. | — |
Secondary
| Measure | Time frame |
|---|---|
| Erythema. Timepoint: Baseline, two weeks after intervention ,four weeks after intervention, eight weeks after intervention, twelve weeks after intervention. Method of measurement: Inspection.;Pruritus. Timepoint: Baseline, two weeks after intervention ,four weeks after intervention, eight weeks after intervention, twelve weeks after intervention. Method of measurement: Questionnaire.;Scaling. Timepoint: Baseline, two weeks after intervention ,four weeks after intervention, eight weeks after intervention, twelve weeks after intervention. Method of measurement: Inspection. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHoda Badakhsh
Kerman University of Medical Sciences
Outcome results
None listed